Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2640) (CBMAB-T1819-YJ)

Name: Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2640)
SKU: CBMAB-T1819-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2640

Application

Immunogen

Human recombinant protein fragment corresponding to amino acids 116-346 of human TFB1M (NP_057104) produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 116-346

More Infomation

Target

Full Name

TFB1M Gene(Protein Coding) Transcription Factor B1, Mitochondrial

Introduction

TFB1M is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. TFB1M also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).

Entrez Gene ID

51106

UniProt ID

Q8WVM0

Alternative Names

Transcription Factor B1, Mitochondrial; S-Adenosylmethionine-6-N, N-Adenosyl(RRNA) Dimethyltransferase 1; Dimethyladenosine Transferase 1, Mitochondrial; Mitochondrial 12S RRNA Dimethylase 1; H-MtTFB1; HTFB1M; MtTFB1; Homolog Of Yeast Mitochondrial Transcription Factor B; Mitochondrial Dimethyladenosine Transferase 1

Function

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

Biological Process

Biological Process rRNA methylationSource:GO_Central1 Publication
Biological Process rRNA modificationSource:Reactome
Biological Process transcription initiation at mitochondrial promoterSource:GO_Central1 Publication

Cellular Location

Mitochondrion

Involvement in disease

Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TFB1M Matched Antibody Pair (1197) (CAT#: APMAB-1197LY)

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Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2645) (CAT#: CBMAB-T1824-YJ)

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2642) (CAT#: CBMAB-T1821-YJ)

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2641) (CAT#: CBMAB-T1820-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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