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Mouse Anti-TFDP1 Recombinant Antibody (5F191) (CBMAB-D2268-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Transcription Factor Dp-1 (TFDP1). The antibody can be used for immunoassay techniques, such as IHC, WB.
See all TFDP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Cattle, Chicken, Mouse, Rat
Clone
5F191
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Bovine Desmoplakin 1
Specificity
Human, Cattle, Chicken, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
transcription factor Dp-1
Introduction
TFDP1 belongs to a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Pseudogenes of this gene are found on chromosomes 1, 15, and X.
Entrez Gene ID
Human7027
Mouse21781
Rat361178
Chicken418739
Cattle534579
UniProt ID
HumanQ14186
MouseQ08639
RatQ4KM53
ChickenF7HG27
CattleQ17QZ4
Alternative Names
Transcription Factor Dp-1; Down-Regulated In Liver Cancer Stem Cells; E2F Dimerization Partner 1; DRTF1-Polypeptide 1; DRTF1; DP1; E2F-Related Transcription Factor; DILC; Dp-1;
Function
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537).
The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Biological Process
Biological Process anoikisSource:Ensembl
Biological Process epidermis developmentSource:Ensembl
Biological Process negative regulation of DNA-binding transcription factor activitySource:ComplexPortal1 Publication
Biological Process negative regulation of fat cell proliferationSource:UniProtKB
Biological Process positive regulation of DNA-binding transcription factor activitySource:UniProtKB1 Publication
Biological Process positive regulation of G1/S transition of mitotic cell cycleSource:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of DNA biosynthetic processSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Biological Process regulation of transcription involved in G1/S transition of mitotic cell cycleSource:ComplexPortal1 Publication
Biological Process transcription by RNA polymerase IISource:CACAO1 Publication
Cellular Location
Nucleus
Cytoplasm
Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1.
PTM
Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.
Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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