Sign in or Register   Sign in or Register
  |  

Mouse Anti-TFDP1 Recombinant Antibody (CBYJT-2655) (CBMAB-T1835-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TFDP1 (Transcription Factor Dp-1). The antibody can be used for immunoassay techniques, such as S-ELISA, ELISA, WB.
See all TFDP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2655
Antibody Isotype
IgG2a, κ
Application
S-ELISA, ELISA, WB

Basic Information

Immunogen
TFDP1 (NP_009042.1, 112 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 112-220

Target

Full Name
transcription factor Dp-1
Introduction
TFDP1 is a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. TFDP1 plays a role as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase.
Entrez Gene ID
7027
UniProt ID
Q14186
Alternative Names
Transcription Factor Dp-1; Down-Regulated In Liver Cancer Stem Cells; E2F Dimerization Partner 1; DRTF1-Polypeptide 1; DRTF1; DP1; E2F-Related Transcription Factor; DILC; Dp-1
Function
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537).
The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Biological Process
Biological Process anoikisSource:Ensembl
Biological Process epidermis developmentSource:Ensembl
Biological Process negative regulation of DNA-binding transcription factor activitySource:ComplexPortal1 Publication
Biological Process negative regulation of fat cell proliferationSource:UniProtKB
Biological Process positive regulation of DNA-binding transcription factor activitySource:UniProtKB1 Publication
Biological Process positive regulation of G1/S transition of mitotic cell cycleSource:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of DNA biosynthetic processSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Biological Process regulation of transcription involved in G1/S transition of mitotic cell cycleSource:ComplexPortal1 Publication
Biological Process transcription by RNA polymerase IISource:CACAO1 Publication
Cellular Location
Nucleus
Cytoplasm
Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1.
PTM
Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.
Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TFDP1 Recombinant Antibody (CBYJT-2655)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare