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TFDP1

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X
Full Name
transcription factor Dp-1
Function
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537).
The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Biological Process
Biological Process anoikisSource:Ensembl
Biological Process epidermis developmentSource:Ensembl
Biological Process negative regulation of DNA-binding transcription factor activitySource:ComplexPortal1 Publication
Biological Process negative regulation of fat cell proliferationSource:UniProtKB
Biological Process positive regulation of DNA-binding transcription factor activitySource:UniProtKB1 Publication
Biological Process positive regulation of G1/S transition of mitotic cell cycleSource:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of DNA biosynthetic processSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Biological Process regulation of transcription involved in G1/S transition of mitotic cell cycleSource:ComplexPortal1 Publication
Biological Process transcription by RNA polymerase IISource:CACAO1 Publication
Cellular Location
Nucleus
Cytoplasm
Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1.
PTM
Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.
Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation.
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Anti-TFDP1 antibodies

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Mouse Anti-TFDP1 Recombinant Antibody (3E4) (CBMAB-A9036-LY)

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Target: TFDP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E4
Application*: WB, E
Datasheet SDS

Mouse Anti-TFDP1 Recombinant Antibody (CBYJT-2655) (CBMAB-T1835-YJ)

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Target: TFDP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2655
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-TFDP1 Recombinant Antibody (CBYJT-2654) (CBMAB-T1834-YJ)

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Target: TFDP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2654
Application*: E, WB
Datasheet SDS

Mouse Anti-TFDP1 Recombinant Antibody (CBYJT-2653) (CBMAB-T1833-YJ)

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Target: TFDP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-2653
Application*: WB
Datasheet SDS

Mouse Anti-TFDP1 Recombinant Antibody (CBYJT-2652) (CBMAB-T1831-YJ)

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Target: TFDP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-2652
Application*: P, WB
Datasheet SDS

Mouse Anti-TFDP1 Recombinant Antibody (CBYJT-2651) (CBMAB-T1830-YJ)

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Target: TFDP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2651
Application*: E, WB
Datasheet SDS

Mouse Anti-TFDP1 Recombinant Antibody (CBYJT-2650) (CBMAB-T1829-YJ)

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Target: TFDP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-2650
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-TFDP1 Recombinant Antibody (TFD10) (CBMAB-D2271-YC)

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Target: TFDP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TFD10
Application*: IH, IPP, WB
Datasheet SDS

Mouse Anti-TFDP1 Recombinant Antibody (DP2.17) (CBMAB-D2269-YC)

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Target: TFDP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Chicken, Mouse, Rat
Clone: DP2.17
Application*: C, WB
Datasheet SDS

Mouse Anti-TFDP1 Recombinant Antibody (5F191) (CBMAB-D2268-YC)

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Target: TFDP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Chicken, Mouse, Rat
Clone: 5F191
Application*: IH, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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