Mouse Anti-TGFBR3 Recombinant Antibody (CBYJT-2818) (CBMAB-T2042-YJ)

Mouse

Human

CBYJT-2818

IgG1

WB, IHC

Human recombinant protein fragment corresponding to amino acids 531-777 of human TGFBR3(NP_003234) produced in E. coli

Human

IgG1

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

PBS, pH 7.3, 1% BSA, 50% Glycerol

0.02% Sodium Azide

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

aa 531-777

TGFBR3 Gene(Protein Coding) Transforming Growth Factor Beta Receptor 3

TGFBR3 encodes the transforming growth factor (TGF)-beta type III receptor. TGFBR3 is a membrane proteoglycan that often plays a role as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of TGFBR3 has been observed in various cancers.

Transforming Growth Factor Beta Receptor 3; Transforming Growth Factor Beta Receptor III; TGF-Beta Receptor Type III; TGF-Beta Receptor Type 3; Betaglycan Proteoglycan; Betaglycan

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

Biological Process animal organ regenerationSource:Ensembl
Biological Process BMP signaling pathwaySource:BHF-UCL1 Publication
Biological Process cardiac epithelial to mesenchymal transitionSource:BHF-UCL1 Publication
Biological Process cardiac muscle cell proliferationSource:BHF-UCL
Biological Process cell migrationSource:BHF-UCL
Biological Process definitive erythrocyte differentiationSource:BHF-UCL
Biological Process definitive hemopoiesisSource:BHF-UCL
Biological Process epicardium-derived cardiac fibroblast cell developmentSource:BHF-UCL
Biological Process epithelial to mesenchymal transitionSource:BHF-UCL1 Publication
Biological Process heart morphogenesisSource:BHF-UCL
Biological Process heart trabecula formationSource:BHF-UCL
Biological Process heart trabecula morphogenesisSource:BHF-UCL
Biological Process immune responseSource:BHF-UCL1 Publication
Biological Process intracellular signal transductionSource:BHF-UCL1 Publication
Biological Process liver developmentSource:BHF-UCL
Biological Process muscular septum morphogenesisSource:BHF-UCL
Biological Process negative regulation of epithelial cell proliferationSource:BHF-UCL
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwaySource:Ensembl
Biological Process outflow tract morphogenesisSource:BHF-UCL
Biological Process pathway-restricted SMAD protein phosphorylationSource:BHF-UCL1 Publication
Biological Process positive regulation of cardiac muscle cell proliferationSource:BHF-UCL
Biological Process positive regulation of transforming growth factor beta receptor signaling pathwaySource:Ensembl
Biological Process regulation of protein bindingSource:Ensembl
Biological Process regulation of transforming growth factor beta receptor signaling pathwaySource:GO_Central1 Publication
Biological Process response to follicle-stimulating hormoneSource:BHF-UCL1 Publication
Biological Process response to hypoxiaSource:Ensembl
Biological Process response to luteinizing hormoneSource:BHF-UCL1 Publication
Biological Process response to prostaglandin ESource:BHF-UCL1 Publication
Biological Process secondary palate developmentSource:BHF-UCL
Biological Process transforming growth factor beta receptor complex assemblySource:Ensembl
Biological Process transforming growth factor beta receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process vasculogenesis involved in coronary vascular morphogenesisSource:BHF-UCL
Biological Process ventricular cardiac muscle tissue morphogenesisSource:BHF-UCL
Biological Process ventricular compact myocardium morphogenesisSource:BHF-UCL
Biological Process ventricular septum morphogenesisSource:BHF-UCL

Secreted
Secreted, extracellular space
Cell membrane
Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.

Extracellular: 21-787
Helical: 788-809
Cytoplasmic: 810-851

Extensively modified by glycosaminoglycan groups (GAG).