TGFBR3

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

Full Name

TGFBR3 Gene(Protein Coding) Transforming Growth Factor Beta Receptor 3

Function

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

Biological Process

Biological Process animal organ regenerationSource:Ensembl
Biological Process BMP signaling pathwaySource:BHF-UCL1 Publication
Biological Process cardiac epithelial to mesenchymal transitionSource:BHF-UCL1 Publication
Biological Process cardiac muscle cell proliferationSource:BHF-UCL
Biological Process cell migrationSource:BHF-UCL
Biological Process definitive erythrocyte differentiationSource:BHF-UCL
Biological Process definitive hemopoiesisSource:BHF-UCL
Biological Process epicardium-derived cardiac fibroblast cell developmentSource:BHF-UCL
Biological Process epithelial to mesenchymal transitionSource:BHF-UCL1 Publication
Biological Process heart morphogenesisSource:BHF-UCL
Biological Process heart trabecula formationSource:BHF-UCL
Biological Process heart trabecula morphogenesisSource:BHF-UCL
Biological Process immune responseSource:BHF-UCL1 Publication
Biological Process intracellular signal transductionSource:BHF-UCL1 Publication
Biological Process liver developmentSource:BHF-UCL
Biological Process muscular septum morphogenesisSource:BHF-UCL
Biological Process negative regulation of epithelial cell proliferationSource:BHF-UCL
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwaySource:Ensembl
Biological Process outflow tract morphogenesisSource:BHF-UCL
Biological Process pathway-restricted SMAD protein phosphorylationSource:BHF-UCL1 Publication
Biological Process positive regulation of cardiac muscle cell proliferationSource:BHF-UCL
Biological Process positive regulation of transforming growth factor beta receptor signaling pathwaySource:Ensembl
Biological Process regulation of protein bindingSource:Ensembl
Biological Process regulation of transforming growth factor beta receptor signaling pathwaySource:GO_Central1 Publication
Biological Process response to follicle-stimulating hormoneSource:BHF-UCL1 Publication
Biological Process response to hypoxiaSource:Ensembl
Biological Process response to luteinizing hormoneSource:BHF-UCL1 Publication
Biological Process response to prostaglandin ESource:BHF-UCL1 Publication
Biological Process secondary palate developmentSource:BHF-UCL
Biological Process transforming growth factor beta receptor complex assemblySource:Ensembl
Biological Process transforming growth factor beta receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process vasculogenesis involved in coronary vascular morphogenesisSource:BHF-UCL
Biological Process ventricular cardiac muscle tissue morphogenesisSource:BHF-UCL
Biological Process ventricular compact myocardium morphogenesisSource:BHF-UCL
Biological Process ventricular septum morphogenesisSource:BHF-UCL

Cellular Location

Secreted
Secreted, extracellular space
Cell membrane
Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.

Topology

Extracellular: 21-787
Helical: 788-809
Cytoplasmic: 810-851

PTM

Extensively modified by glycosaminoglycan groups (GAG).