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Mouse Anti-THAP1 Recombinant Antibody (CBYJT-2897) (CBMAB-T2131-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to THAP1 (THAP Domain Containing 1). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all THAP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2897
Antibody Isotype
IgG2b, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-214 from human THAP1 (AAH21721) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-214

Target

Full Name
THAP domain containing, apoptosis associated protein 1
Introduction
THAP1 contains a THAP domain, a conserved DNA-binding domain. It colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and plays a role as a proapoptotic factor that links PAWR to PML nuclear bodies.
Entrez Gene ID
55145
UniProt ID
Q9NVV9
Alternative Names
THAP Domain Containing 1; THAP Domain Containing, Apoptosis Associated Protein 1; Dystonia 6, Torsion (Autosomal Dominant); THAP Domain-Containing Protein 1; Nuclear Proapoptotic Factor; THAP Domain Protein 1; 4833431A01Rik; DYT6
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Biological Process
Biological Process cell cycleSource:UniProtKB-KW
Biological Process DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process endothelial cell proliferationSource:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process regulation of mitotic cell cycleSource:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Cellular Location
Nucleus, nucleoplasm
Nucleus, PML body
Involvement in disease
Dystonia 6, torsion (DYT6):
A primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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