Mouse Anti-THAP1 Recombinant Antibody (CBYJT-2898) (CBMAB-T2132-YJ)

Name: Mouse Anti-THAP1 Recombinant Antibody (CBYJT-2898)
SKU: CBMAB-T2132-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2898

Application

ELISA, WB, FC

Immunogen

Recombinant fragment of human THAP1 expressed in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS

Preservative

0.05% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

THAP domain containing, apoptosis associated protein 1

Introduction

THAP1 contains a THAP domain, a conserved DNA-binding domain. It colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and plays a role as a proapoptotic factor that links PAWR to PML nuclear bodies.

Entrez Gene ID

55145

UniProt ID

Q9NVV9

Alternative Names

THAP Domain Containing 1; THAP Domain Containing, Apoptosis Associated Protein 1; Dystonia 6, Torsion (Autosomal Dominant); THAP Domain-Containing Protein 1; Nuclear Proapoptotic Factor; THAP Domain Protein 1; 4833431A01Rik; DYT6

Function

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.

Biological Process

Biological Process cell cycleSource:UniProtKB-KW
Biological Process DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process endothelial cell proliferationSource:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process regulation of mitotic cell cycleSource:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication

Cellular Location

Nucleus, nucleoplasm
Nucleus, PML body

Involvement in disease

Dystonia 6, torsion (DYT6):
A primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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