THAP1

The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
Full Name
THAP domain containing, apoptosis associated protein 1
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Biological Process
Biological Process cell cycleSource:UniProtKB-KW
Biological Process DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process endothelial cell proliferationSource:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process regulation of mitotic cell cycleSource:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Cellular Location
Nucleus, nucleoplasm
Nucleus, PML body
Involvement in disease
Dystonia 6, torsion (DYT6):
A primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.
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Anti-THAP1 antibodies

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Mouse Anti-THAP1 Recombinant Antibody (2C1-2F2) (CBMAB-A9076-LY)

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Target: THAP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2C1-2F2
Application*: WB, E
Datasheet SDS

Mouse Anti-THAP1 Recombinant Antibody (CBYJT-2900) (CBMAB-T2134-YJ)

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Target: THAP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-2900
Application*: WB
Datasheet SDS

Mouse Anti-THAP1 Recombinant Antibody (CBYJT-2899) (CBMAB-T2133-YJ)

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Target: THAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2899
Application*: E, WB, IF, IC, F
Datasheet SDS

Mouse Anti-THAP1 Recombinant Antibody (CBYJT-2898) (CBMAB-T2132-YJ)

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Target: THAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2898
Application*: E, WB, F
Datasheet SDS

Mouse Anti-THAP1 Recombinant Antibody (CBYJT-2897) (CBMAB-T2131-YJ)

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Target: THAP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2897
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-THAP1 Recombinant Antibody (CBT2096) (V2LY-0625-LY287)

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Target: THAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2096
Application*: IC, F
Datasheet SDS

Mouse Anti-THAP1 Recombinant Antibody (CBT3895) (V2LY-0625-LY286)

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Target: THAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3895
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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