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Mouse Anti-TIGIT Recombinant Antibody (CBT2084) (V2LY-0625-LY1024)


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Tested Data
Mouse Anti-TIGIT Recombinant Antibody (CBT2084) (V2LY-0625-LY1024) in ELISA
Mouse Anti-TIGIT Recombinant Antibody (CBT2084) (V2LY-0625-LY1024) in ELISA
Mouse Anti-TIGIT Recombinant Antibody (CBT2084) (V2LY-0625-LY1024) in WB
Mouse Anti-TIGIT Recombinant Antibody (CBT2084) (V2LY-0625-LY1024) in WB
Mouse Anti-TIGIT Recombinant Antibody (CBT2084) (V2LY-0625-LY1024) in WB
Mouse Anti-TIGIT Recombinant Antibody (CBT2084) (V2LY-0625-LY1024) in WB
Mouse Anti-TIGIT Recombinant Antibody (CBT2084) (V2LY-0625-LY1024) in FC
Mouse Anti-TIGIT Recombinant Antibody (CBT2084) (V2LY-0625-LY1024) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2084
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human TIGIT (AA: extra 22-141) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
T cell immunoreceptor with Ig and ITIM domains
Entrez Gene ID
201633
Alternative Names
T Cell Immunoreceptor With Ig And ITIM Domains; V-Set And Immunoglobulin Domain-Containing Protein 9; V-Set And Transmembrane Domain-Containing Protein 3; T-Cell Immunoreceptor With Ig And ITIM Domains; VSIG9, VSTM3; VSIG9;
Function
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Biological Process
Biological Process negative regulation of interleukin-12 productionSource:UniProtKB1 Publication
Biological Process negative regulation of T cell activationSource:MGI1 Publication
Biological Process positive regulation of interleukin-10 productionSource:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 22-141
Helical: 142-162
Cytoplasmic: 163-244
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For research use only. Not intended for any clinical use.

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