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TIGIT

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
Full Name
T cell immunoreceptor with Ig and ITIM domains
Alternative Names
T Cell Immunoreceptor With Ig And ITIM Domains; V-Set And Immunoglobulin Domain-Containing Protein 9; V-Set And Transmembrane Domain-Containing Protein 3; T-Cell Immunoreceptor With Ig And ITIM Domains; VSIG9, VSTM3; VSIG9;
Function
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Biological Process
Biological Process negative regulation of interleukin-12 productionSource:UniProtKB1 Publication
Biological Process negative regulation of T cell activationSource:MGI1 Publication
Biological Process positive regulation of interleukin-10 productionSource:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 22-141
Helical: 142-162
Cytoplasmic: 163-244
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Anti-TIGIT antibodies

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Mouse Anti-TIGIT Recombinant Antibody (CBYJT-3140) (CBMAB-T2411-YJ)

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Target: TIGIT
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYJT-3140
Application*: F
Datasheet SDS

Mouse Anti-TIGIT Recombinant Antibody (AG177) (V2LY-0524-LY54)

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Target: TIGIT
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: AG177
Application*: B, F, In Vivo
In Vivo Assay Functional Assay
Datasheet SDS

Mouse Anti-TIGIT Recombinant Antibody (CBT2084) (V2LY-0625-LY1024)

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Target: TIGIT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2084
Application*: F
Datasheet SDS

Rabbit Anti-TIGIT Recombinant Antibody (CBR047F) (CBMAB-BT085LY)

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Target: TIGIT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR047F
Application*: WB, IHC, IHC-IF
Datasheet SDS

Rabbit Anti-TIGIT Recombinant Antibody (E6L7H) (CBMAB-CP2771-LY)

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Target: TIGIT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E6L7H
Application*: WB, IP
Datasheet SDS

Recombinant Mouse Anti-TIGIT Recombinant Antibody (13E7) (CBMAB-XB1141-YC)

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Target: TIGIT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 13E7
Application*: E, IH, WB
Datasheet SDS

Rat Anti-Tigit Recombinant Antibody (CBYJT-3145) (CBMAB-T2416-YJ)

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Target: Tigit
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3145
Application*: F
Datasheet SDS

Mouse Anti-Tigit Recombinant Antibody (CBYJT-3144) (CBMAB-T2415-YJ)

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Target: Tigit
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-3144
Application*: F
Datasheet SDS

Mouse Anti-TIGIT Recombinant Antibody (CBYJT-3143) (CBMAB-T2414-YJ)

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Target: TIGIT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3143
Application*: F
Datasheet SDS

Mouse Anti-TIGIT Recombinant Antibody (CBYJT-3142) (CBMAB-T2413-YJ)

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Target: TIGIT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3142
Application*: F
Datasheet SDS

Mouse Anti-TIGIT Recombinant Antibody (CBYJT-3141) (CBMAB-T2412-YJ)

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Target: TIGIT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3141
Application*: F, MC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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