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TIGIT

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]
Full Name
T cell immunoreceptor with Ig and ITIM domains
Function
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Biological Process
Biological Process negative regulation of interleukin-12 productionSource:UniProtKB1 Publication
Biological Process negative regulation of T cell activationSource:MGI1 Publication
Biological Process positive regulation of interleukin-10 productionSource:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 22-141
Helical: 142-162
Cytoplasmic: 163-244

Anti-TIGIT antibodies

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Target: TIGIT
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYJT-3140
Application*: F
Target: TIGIT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3141
Application*: F, MC
Target: Tigit
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-3144
Application*: F
Target: Tigit
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3145
Application*: F
Target: TIGIT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3142
Application*: F
Target: TIGIT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3143
Application*: F
Target: TIGIT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 13E7
Application*: E, IH, WB
Target: TIGIT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E6L7H
Application*: WB, IP
Target: TIGIT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR047F
Application*: WB, IHC, IHC-IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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