TIGIT
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
Full Name
T cell immunoreceptor with Ig and ITIM domains
Alternative Names
T Cell Immunoreceptor With Ig And ITIM Domains; V-Set And Immunoglobulin Domain-Containing Protein 9; V-Set And Transmembrane Domain-Containing Protein 3; T-Cell Immunoreceptor With Ig And ITIM Domains; VSIG9, VSTM3; VSIG9;
Function
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Biological Process
Biological Process negative regulation of interleukin-12 productionSource:UniProtKB1 Publication
Biological Process negative regulation of T cell activationSource:MGI1 Publication
Biological Process positive regulation of interleukin-10 productionSource:UniProtKB1 Publication
Biological Process negative regulation of T cell activationSource:MGI1 Publication
Biological Process positive regulation of interleukin-10 productionSource:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 22-141
Helical: 142-162
Cytoplasmic: 163-244
Helical: 142-162
Cytoplasmic: 163-244
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Anti-TIGIT antibodies
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CompareTarget: TIGIT
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYJT-3140
Application*: F
Target: TIGIT
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: AG177
Application*: B, F, In Vivo
Target: TIGIT
Sensitivity: 0.019 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-138
Tag: hFc Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: Fc Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: His & AVI Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: hFc Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: His Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: Fc Tag
Target: TIGIT
Expressed Host: CHO Cells
Sequence: Amino Acid: 22-141
Tag: His Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: hFc Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: hFc & AVI Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: His Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: His & AVI Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: hFc Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 22-141
Tag: His & AVI Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 22-141
Tag: His Tag
Target: TIGIT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-209
Tag: hFc Tag
Target: TIGIT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2084
Application*: F
Target: TIGIT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR047F
Application*: WB, IHC, IHC-IF
Target: TIGIT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E6L7H
Application*: WB, IP
Target: TIGIT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 13E7
Application*: E, IH, WB
Target: Tigit
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3145
Application*: F
Target: Tigit
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-3144
Application*: F
Target: TIGIT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3143
Application*: F
Target: TIGIT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3142
Application*: F
Target: TIGIT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3141
Application*: F, MC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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