Human Recombinant TIGIT protein, Dimer, ECD, His Tag (V2LY-0526-LY7218)

Name: Human Recombinant TIGIT protein, Dimer, ECD, His Tag
SKU: V2LY-0526-LY7218
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant TIGIT protein, Dimer, ECD, His Tag consist of Amino Acid: 22-141 and predicts a molecular mass of 28.81 kDa.

Molecule Mass

28.81 kDa

Polymeric

Dimer

Protein Domain

ECD

Verified

HPLC

Sequence

Amino Acid: 22-141

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC. ≥95% as determined by SEC-MALS(Routinely tested).

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

T cell immunoreceptor with Ig and ITIM domains

Alternative Names

T Cell Immunoreceptor With Ig And ITIM Domains; V-Set And Immunoglobulin Domain-Containing Protein 9; V-Set And Transmembrane Domain-Containing Protein 3; T-Cell Immunoreceptor With Ig And ITIM Domains; VSIG9, VSTM3; VSIG9;

Function

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Biological Process

Biological Process negative regulation of interleukin-12 productionSource:UniProtKB1 Publication
Biological Process negative regulation of T cell activationSource:MGI1 Publication
Biological Process positive regulation of interleukin-10 productionSource:UniProtKB1 Publication

Cellular Location

Cell membrane

Topology

Extracellular: 22-141
Helical: 142-162
Cytoplasmic: 163-244

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant TIGIT protein, ECD, hFc Tag (CAT#: V2LY-0526-LY1653)

Human Recombinant TIGIT protein, Dimer, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY7219)

Human Recombinant TIGIT protein, ECD, hFc Tag (CAT#: V2LY-0526-LY7220)

Human Recombinant TIGIT protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY7221)

Human Recombinant TIGIT protein, ECD, His Tag (CAT#: V2LY-0526-LY7222)

Human Recombinant TIGIT protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY7223)

Human Recombinant TIGIT protein, Biotin Conjugated, hFc Tag (CAT#: V2LY-0526-LY7224)

Human Recombinant TIGIT protein, His Tag (CAT#: V2LY-0526-LY7225)

Human Recombinant TIGIT protein, Fc Tag (CAT#: V2LY-0526-LY7226)

Mouse Recombinant TIGIT protein, ECD, His Tag (CAT#: V2LY-0526-LY8973)

Related Products

Human Recombinant TIGIT protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY7221)

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Mouse Anti-TIGIT Recombinant Antibody (CBYJT-3141) (CAT#: CBMAB-T2412-YJ)

Mouse Anti-Tigit Recombinant Antibody (CBYJT-3144) (CAT#: CBMAB-T2415-YJ)

Mouse Recombinant TIGIT protein, hFc Tag (CAT#: V2LY-0526-LY8974)

Rabbit Anti-TIGIT Recombinant Antibody (E6L7H) (CAT#: CBMAB-CP2771-LY)

Cynomolgus Recombinant TIGIT protein, ECD, hFc Tag (CAT#: V2LY-0526-LY1653)

Mouse Recombinant TIGIT protein, Fc Tag (CAT#: V2LY-0526-LY8976)

Mouse Anti-TIGIT Recombinant Antibody (CBT2084) (CAT#: V2LY-0625-LY1024)

Rat Anti-Tigit Recombinant Antibody (CBYJT-3145) (CAT#: CBMAB-T2416-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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