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Mouse Anti-TIGIT Recombinant Antibody (CBYJT-3141) (CBMAB-T2412-YJ)

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Basic Information

Host Animal
Mouse
Clone
CBYJT-3141
Application
FC, CyTOF
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TIGIT, Met1-Pro141, Accession # Q495A1
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-141
More Infomation

Target

Full Name
T cell immunoreceptor with Ig and ITIM domains
Introduction
TIGIT is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. TIGIT is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
Entrez Gene ID
201633
UniProt ID
Q495A1
Alternative Names
T Cell Immunoreceptor With Ig And ITIM Domains; V-Set And Immunoglobulin Domain-Containing Protein 9; V-Set And Transmembrane Domain-Containing Protein 3; T-Cell Immunoreceptor With Ig And ITIM Domains; VSIG9, VSTM3; VSIG9
Function
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Biological Process
Biological Process negative regulation of interleukin-12 productionSource:UniProtKB1 Publication
Biological Process negative regulation of T cell activationSource:MGI1 Publication
Biological Process positive regulation of interleukin-10 productionSource:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 22-141
Helical: 142-162
Cytoplasmic: 163-244
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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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