Mouse Anti-Tigit Recombinant Antibody (CBYJT-3144) (CBMAB-T2415-YJ)

Name: Mouse Anti-Tigit Recombinant Antibody (CBYJT-3144)
SKU: CBMAB-T2415-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3144

Application

Specificity

Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.0

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

T cell immunoreceptor with Ig and ITIM domains

Introduction

Tigit functions in negative regulation of interleukin-12 production, negative regulation of T cell activation, positive regulation of interleukin-10 production.

Entrez Gene ID

100043314

UniProt ID

A0A0B4J1G6

Alternative Names

Vstm3

Function

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Biological Process

Biological Process negative regulation of interleukin-12 productionSource:UniProtKB1 Publication
Biological Process negative regulation of T cell activationSource:MGI1 Publication
Biological Process positive regulation of interleukin-10 productionSource:UniProtKB1 Publication

Cellular Location

Cell membrane

Topology

Extracellular: 22-141
Helical: 142-162
Cytoplasmic: 163-244

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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