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Mouse Anti-TIMD4 Recombinant Antibody (CBT4358) (V2LY-0625-LY1639)


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Tested Data
Mouse Anti-TIMD4 Recombinant Antibody (CBT4358) (V2LY-0625-LY1639) in ELISA
Mouse Anti-TIMD4 Recombinant Antibody (CBT4358) (V2LY-0625-LY1639) in ELISA
Mouse Anti-TIMD4 Recombinant Antibody (CBT4358) (V2LY-0625-LY1639) in WB
Mouse Anti-TIMD4 Recombinant Antibody (CBT4358) (V2LY-0625-LY1639) in WB
Mouse Anti-TIMD4 Recombinant Antibody (CBT4358) (V2LY-0625-LY1639) in WB
Mouse Anti-TIMD4 Recombinant Antibody (CBT4358) (V2LY-0625-LY1639) in WB
Mouse Anti-TIMD4 Recombinant Antibody (CBT4358) (V2LY-0625-LY1639) in WB
Mouse Anti-TIMD4 Recombinant Antibody (CBT4358) (V2LY-0625-LY1639) in WB
Mouse Anti-TIMD4 Recombinant Antibody (CBT4358) (V2LY-0625-LY1639) in FC
Mouse Anti-TIMD4 Recombinant Antibody (CBT4358) (V2LY-0625-LY1639) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4358
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Purified recombinant fragment of human TIMD4 (AA: extra 25-314) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
91937
Function
Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation (PubMed:17960135).
Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:18354194, PubMed:18367551).
Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (By similarity).
Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (PubMed:31263038).
Biological Process
Biological Process apoptotic cell clearanceSource:MGI1 Publication
Biological Process cytoskeletal rearrangement involved in phagocytosis, engulfmentSource:GO_Central1 Publication
Cellular Location
Membrane
Topology
Extracellular: 23-279
Helical: 280-300
Cytoplasmic: 301-343
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For research use only. Not intended for any clinical use.

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