TIMD4
TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein import. Gene Ontology (GO) annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TIMM17B.
Full Name
TIMD4 Gene(Protein Coding) T Cell Immunoglobulin And Mucin Domain Containing 4
Function
Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation (PubMed:17960135).
Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:18354194, PubMed:18367551).
Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (By similarity).
Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (PubMed:31263038).
Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:18354194, PubMed:18367551).
Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (By similarity).
Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (PubMed:31263038).
Biological Process
Biological Process apoptotic cell clearanceSource:MGI1 Publication
Biological Process cytoskeletal rearrangement involved in phagocytosis, engulfmentSource:GO_Central1 Publication
Biological Process cytoskeletal rearrangement involved in phagocytosis, engulfmentSource:GO_Central1 Publication
Cellular Location
Membrane
Topology
Extracellular: 23-279
Helical: 280-300
Cytoplasmic: 301-343
Helical: 280-300
Cytoplasmic: 301-343
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Anti-TIMD4 antibodies
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CompareTarget: TIMD4
Sensitivity: 0.031 ng/mL
Detection Range: 0.05-18 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: TIMD4
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-279
Tag: His Tag
Target: TIMD4
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-315
Tag: His Tag
Target: TIMD4
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-315
Tag: His Tag
Target: TIMD4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4478
Application*: IC, F
Target: TIMD4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4358
Application*: WB, F
Target: TIMD4
Host: Armenian hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBHb085
Application*: FC, FuncS, Immuno assays, IF
Target: TIMD4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-3595
Application*: E
Target: Timd4
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3161
Application*: IA, IC, IF, FN
Target: Timd4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: RMT4-54
Application*: FN, P, IC, IF, F
Target: Timd4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3160
Application*: F, IC, IF, N
Target: Timd4
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: Kat5-18
Application*: F, FN, IA, IF
Target: Timd4
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3159
Application*: F
Target: Timd4
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYJT-3158
Application*: F
Target: TIMD4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3157
Application*: F
Target: TIMD4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3156
Application*: F, MC
Target: TIMD4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3155
Application*: E, IF, IP
Target: TIMD4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3154
Application*: E, IF, IP
Target: TIMD4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3153
Application*: E, IF, IP
Target: TIMD4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3152
Application*: E
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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