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Rabbit Anti-TIMD4 Recombinant Antibody (CBYJT-3152) (CBMAB-T2424-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TIMD4 (T Cell Immunoglobulin And Mucin Domain Containing 4). The antibody can be used for immunoassay techniques, such as ELISA.
See all TIMD4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJT-3152
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human TIM4 protein. This antibody was obtained from a rabbit immunized with purified, recombinant Human TIM4
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TIMD4 Gene(Protein Coding) T Cell Immunoglobulin And Mucin Domain Containing 4
Introduction
TIMD4 is a phosphatidylserine receptor that enhances the engulfment of apoptotic cells. TIMD4 is involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).
Entrez Gene ID
91937
UniProt ID
Q96H15
Alternative Names
T Cell Immunoglobulin And Mucin Domain Containing 4; T-Cell Immunoglobulin And Mucin Domain Containing 4; T-Cell Immunoglobulin Mucin Receptor 4; T-Cell Membrane Protein 4; TIMD-4; TIM-4; TIM4; T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4; SMUCKLER
Function
Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation (PubMed:17960135).
Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:18354194, PubMed:18367551).
Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (By similarity).
Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (PubMed:31263038).
Biological Process
Biological Process apoptotic cell clearanceSource:MGI1 Publication
Biological Process cytoskeletal rearrangement involved in phagocytosis, engulfmentSource:GO_Central1 Publication
Cellular Location
Membrane
Topology
Extracellular: 23-279
Helical: 280-300
Cytoplasmic: 301-343
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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