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Rat Anti-Timd4 Recombinant Antibody (RMT4-54) (CBMAB-T2434-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Timd4 (T cell immunoglobulin and mucin domain containing 4). The antibody can be used for immunoassay techniques, such as FuncS, IHC-P, ICC, IF, FC.
See all Timd4 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
RMT4-54
Antibody Isotype
IgG2a
Application
FuncS, IHC-P, ICC, IF, FC

Basic Information

Immunogen
Mouse TIMD4 (amino acids 1-288), coupled with the Fc portion of mouse IgG2a
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-288

Target

Full Name
TIMD4 Gene(Protein Coding) T Cell Immunoglobulin And Mucin Domain Containing 4
Introduction
Timd4 is a phosphatidylserine receptor that enhances the engulfment of apoptotic cells. It is involved in regulating T-cell proliferation and lymphotoxin signaling. Timd4 is a ligand for HAVCR1/TIMD1.
Entrez Gene ID
276891
UniProt ID
Q6U7R4
Alternative Names
Tim4; TIM-4; B430010N18Rik
Function
Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation (PubMed:17960135).
Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:18354194, PubMed:18367551).
Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (By similarity).
Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (PubMed:31263038).
Biological Process
Biological Process apoptotic cell clearanceSource:MGI1 Publication
Biological Process cytoskeletal rearrangement involved in phagocytosis, engulfmentSource:GO_Central1 Publication
Cellular Location
Membrane
Topology
Extracellular: 23-279
Helical: 280-300
Cytoplasmic: 301-343
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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