Mouse Recombinant TIMD4 protein, His Tag (V2LY-0526-LY8982)

Name: Mouse Recombinant TIMD4 protein, His Tag
SKU: V2LY-0526-LY8982
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant TIMD4 protein, His Tag consist of Amino Acid: 1-279 and predicts a molecular mass of 29.3 kDa.

Molecule Mass

29.3 kDa

Sequence

Amino Acid: 1-279

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>94% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

TIMD4 Gene(Protein Coding) T Cell Immunoglobulin And Mucin Domain Containing 4

Function

Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation (PubMed:17960135).
Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:18354194, PubMed:18367551).
Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (By similarity).
Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (PubMed:31263038).

Biological Process

Biological Process apoptotic cell clearanceSource:MGI1 Publication
Biological Process cytoskeletal rearrangement involved in phagocytosis, engulfmentSource:GO_Central1 Publication

Cellular Location

Membrane

Topology

Extracellular: 23-279
Helical: 280-300
Cytoplasmic: 301-343

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant TIMD4 protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY7236)

Human Recombinant TIMD4 protein, His Tag (CAT#: V2LY-0526-LY7237)

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Mouse Anti-TIMD4 Recombinant Antibody (CBYJT-3153) (CAT#: CBMAB-T2425-YJ)

Human Recombinant TIMD4 protein, His Tag (CAT#: V2LY-0526-LY7237)

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Rabbit Anti-TIMD4 Recombinant Antibody (CBXS-3595) (CAT#: CBMAB-S0883-CQ)

Hamster Anti-Timd4 Recombinant Antibody (CBYJT-3161) (CAT#: CBMAB-T2435-YJ)

Rat Anti-Timd4 Recombinant Antibody (CBYJT-3159) (CAT#: CBMAB-T2431-YJ)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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