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Rabbit Anti-TIMD4 Recombinant Antibody (CBXS-3595) (CBMAB-S0883-CQ)

This product is a rabbit antibody that recognizes TIMD4. The antibody CBXS-3595 can be used for immunoassay techniques such as: ELISA.
See all TIMD4 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBXS-3595
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Mouse TIM4/TIMD4 protein
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TIMD4 Gene(Protein Coding) T Cell Immunoglobulin And Mucin Domain Containing 4
Introduction
TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein import. Gene Ontology (GO) annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TIMM17B.
Entrez Gene ID
276891
UniProt ID
Q6U7R4
Alternative Names
B430010N18Rik; TIM-4; Tim4
Function
Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation (PubMed:17960135).
Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:18354194, PubMed:18367551).
Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (By similarity).
Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (PubMed:31263038).
Biological Process
Biological Process apoptotic cell clearanceSource:MGI1 Publication
Biological Process cytoskeletal rearrangement involved in phagocytosis, engulfmentSource:GO_Central1 Publication
Cellular Location
Membrane
Topology
Extracellular: 23-279
Helical: 280-300
Cytoplasmic: 301-343
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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