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Rabbit Anti-TIMP1 Recombinant Antibody (D10E6) (CBMAB-CP2775-LY)

The product is antibody recognizes TIMP1. The antibody D10E6 immunoassay techniques such as: WB.
See all TIMP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D10E6
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala134 of human TIMP1 protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TIMP1 Gene(Protein Coding) TIMP Metallopeptidase Inhibitor 1
Introduction
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human7076
Monkey574348
UniProt ID
HumanP01033
MonkeyQ95KL9
Alternative Names
TIMP Metallopeptidase Inhibitor 1; Tissue Inhibitor Of Metalloproteinases 1; Fibroblast Collagenase Inhibitor; Collagenase Inhibitor; TIMP-1; CLGI; TIMP; EPA;
Function
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Biological Process
Biological Process agingSource:Ensembl
Biological Process cartilage developmentSource:Ensembl
Biological Process cell activationSource:Ensembl
Biological Process cellular response to UV-ASource:UniProtKB1 Publication
Biological Process connective tissue replacement involved in inflammatory response wound healingSource:Ensembl
Biological Process negative regulation of apoptotic processSource:Ensembl
Biological Process negative regulation of catalytic activitySource:UniProtKB1 Publication
Biological Process negative regulation of endopeptidase activitySource:UniProtKB1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:UniProtKB1 Publication
Biological Process negative regulation of metallopeptidase activitySource:UniProtKB1 Publication
Biological Process negative regulation of trophoblast cell migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of cell population proliferationSource:UniProtKB1 Publication
Biological Process regulation of integrin-mediated signaling pathwaySource:UniProtKB1 Publication
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to organic substanceSource:GO_Central1 Publication
Biological Process response to peptide hormoneSource:Ensembl
Cellular Location
Secreted
PTM
The activity of TIMP1 is dependent on the presence of disulfide bonds.
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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