Human Recombinant TIMP1 protein (V2LY-0526-LY7240)

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Datasheet
SDS
Request for COA
Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host
HEK293 Cells
Protein Species
Human
Protein Construction
This product is Human Recombinant TIMP1 protein consist of Amino Acid: 24-207 and predicts a molecular mass of 21 kDa.
Molecule Mass
21 kDa
Verified
HPLC
Sequence
Amino Acid: 24-207
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
≥97% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile Tirs, NaCl, Glycerol
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
TIMP1 Gene(Protein Coding) TIMP Metallopeptidase Inhibitor 1
Function
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Biological Process
Biological Process agingSource:Ensembl
Biological Process cartilage developmentSource:Ensembl
Biological Process cell activationSource:Ensembl
Biological Process cellular response to UV-ASource:UniProtKB1 Publication
Biological Process connective tissue replacement involved in inflammatory response wound healingSource:Ensembl
Biological Process negative regulation of apoptotic processSource:Ensembl
Biological Process negative regulation of catalytic activitySource:UniProtKB1 Publication
Biological Process negative regulation of endopeptidase activitySource:UniProtKB1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:UniProtKB1 Publication
Biological Process negative regulation of metallopeptidase activitySource:UniProtKB1 Publication
Biological Process negative regulation of trophoblast cell migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of cell population proliferationSource:UniProtKB1 Publication
Biological Process regulation of integrin-mediated signaling pathwaySource:UniProtKB1 Publication
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to organic substanceSource:GO_Central1 Publication
Biological Process response to peptide hormoneSource:Ensembl
Cellular Location
Secreted
PTM
The activity of TIMP1 is dependent on the presence of disulfide bonds.
N-glycosylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant TIMP1 protein, hFc Tag (CAT#: V2LY-0526-LY7238)

Human Recombinant TIMP1 protein, His Tag (CAT#: V2LY-0526-LY7239)

Mouse Recombinant TIMP1 protein (CAT#: V2LY-0526-LY8983)

Rat Recombinant TIMP1 protein (CAT#: V2LY-0526-LY9608)

TIMP1 Matched Antibody Pair (1207) (CAT#: APMAB-1207LY)

Antibody Pairs

TIMP1 Matched Antibody Pair (1207) (CAT#: APMAB-1207LY)

Related Products

Mouse Anti-TIMP1 Recombinant Antibody (CBYJT-3196) (CAT#: CBMAB-T2471-YJ)

Mouse Anti-TIMP1 Recombinant Antibody (CBYJT-3198) (CAT#: CBMAB-T2473-YJ)

Human Recombinant TIMP1 protein, His Tag (CAT#: V2LY-0526-LY7239)

Rat Recombinant TIMP1 protein (CAT#: V2LY-0526-LY9608)

Recombinant Mouse Anti-TIMP1 Recombinant Antibody (2A5) (CAT#: CBMAB-XB1142-YC)

Rat Anti-Timp1 Recombinant Antibody (CBYJT-3202) (CAT#: CBMAB-T2477-YJ)

Mouse Anti-Timp1 Recombinant Antibody (CBYJT-3205) (CAT#: CBMAB-T2480-YJ)

Mouse Anti-TIMP1 Recombinant Antibody (CB142A) (CAT#: CBMAB-CA142LY)

Mouse Anti-Timp1 Recombinant Antibody (CBYJT-3206) (CAT#: CBMAB-T2481-YJ)

Mouse Anti-TIMP1 Recombinant Antibody (8B4E9) (CAT#: CBMAB-R4292-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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