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Mouse Anti-Timp2 Recombinant Antibody (F27P3A4) (CBMAB-T2496-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Timp2 (Tissue Inhibitor Of Metalloproteinase 2). The antibody can be used for immunoassay techniques, such as ICC, IF, IHC, IHC-P, WB.
See all Timp2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
F27P3A4
Antibody Isotype
IgG2
Application
ICC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues D(56) S G N D I Y G N P I(66) of mouse TIMP-2
Specificity
Mouse, Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 1 mg/mL BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TIMP2 Gene(Protein Coding) TIMP Metallopeptidase Inhibitor 2
Introduction
Timp2 functions in processes like aging, central nervous system development, negative regulation of cell proliferation, negative regulation of metallopeptidase activity, negative regulation of mitotic cell cycle.
Entrez Gene ID
Human7077
Mouse21858
UniProt ID
HumanP16035
MouseP25785
Alternative Names
Timp-2; D11Bwg1104e
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Biological Process
Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:GO_Central1 Publication
Biological Process negative regulation of metallopeptidase activitySource:UniProtKB1 Publication
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to organic substanceSource:GO_Central1 Publication
Cellular Location
Secreted
PTM
The activity of TIMP2 is dependent on the presence of disulfide bonds.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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