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Mouse Anti-TIMP2 Recombinant Antibody (T2-101) (CBMAB-T2490-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TIMP2 (TIMP Metallopeptidase Inhibitor 2). The antibody can be used for immunoassay techniques, such as IP, WB.
See all TIMP2 antibodies
Published Data
Fig.1 Western blot showing the production of TIMP-2 from CAL-27 and SCC-25 cells treated with/without CSC (100 mg/ml) for 3 and 7 days.
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Fig.2 Western blot analyses for TIMP-2 of the membrane extracts from human gingival fibroblasts treated with different concentrations of cigarette smoke condensate (0–400 lg/mL) for 72 h.
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Fig.3 Western blotting of TIMP-2.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
T2-101
Antibody Isotype
IgG1
Application
IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
10 mM PBS, pH 7.4, 0.2% BSA
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TIMP2 Gene(Protein Coding) TIMP Metallopeptidase Inhibitor 2
Introduction
TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, TIMP2 may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Entrez Gene ID
7077
UniProt ID
P16035
Alternative Names
TIMP Metallopeptidase Inhibitor 2; Tissue Inhibitor Of Metalloproteinases 2; CSC-21K; Tissue Inhibitor Of Metalloproteinase 2; Testicular Secretory Protein Li 57; Metalloproteinase Inhibitor 2; TIMP-2; DDC8
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Biological Process
Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:GO_Central1 Publication
Biological Process negative regulation of metallopeptidase activitySource:UniProtKB1 Publication
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to organic substanceSource:GO_Central1 Publication
Cellular Location
Secreted
PTM
The activity of TIMP2 is dependent on the presence of disulfide bonds.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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