This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Full Name
TIMP2 Gene(Protein Coding) TIMP Metallopeptidase Inhibitor 2
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Biological Process
Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication Biological Process negative regulation of membrane protein ectodomain proteolysisSource:GO_Central1 Publication Biological Process negative regulation of metallopeptidase activitySource:UniProtKB1 Publication Biological Process response to cytokineSource:GO_Central1 Publication Biological Process response to hormoneSource:GO_Central1 Publication Biological Process response to organic substanceSource:GO_Central1 Publication
Cellular Location
Secreted
PTM
The activity of TIMP2 is dependent on the presence of disulfide bonds.
Loading...
Datasheet