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TIMP2

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Full Name
TIMP2 Gene(Protein Coding) TIMP Metallopeptidase Inhibitor 2
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Biological Process
Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:GO_Central1 Publication
Biological Process negative regulation of metallopeptidase activitySource:UniProtKB1 Publication
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to organic substanceSource:GO_Central1 Publication
Cellular Location
Secreted
PTM
The activity of TIMP2 is dependent on the presence of disulfide bonds.
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Anti-TIMP2 antibodies

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Mouse Anti-TIMP2 Recombinant Antibody (CBYJT-3215) (CBMAB-T2492-YJ)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Cattle, Guinea pig, Rabbit, Zebrafish
Clone: CBYJT-3215
Application*: WB, F, IC, IF, P, MC
Datasheet SDS

Rabbit Anti-TIMP2 Recombinant Antibody (D18B7) (CBMAB-CP2776-LY)

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Target: TIMP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: D18B7
Application*: WB
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (5D7) (CBMAB-A9112-LY)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5D7
Application*: WB, E
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (5B11) (CBMAB-A9111-LY)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5B11
Application*: WB, E
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (4F5) (CBMAB-A9110-LY)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F5
Application*: WB, E
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (1C3) (CBMAB-A9109-LY)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C3
Application*: WB, E
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (CBCNC-712) (CBMAB-C4329-CN)

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Target: TIMP2
Host: Mouse
Specificity: Rat
Clone: CBCNC-712
Application*: WB, ICC, P, IH-F, E
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (CBCNC-711) (CBMAB-C4328-CN)

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Target: TIMP2
Host: Mouse
Specificity: Human
Clone: CBCNC-711
Application*: WB, ICC, P, IH-F, E
Datasheet SDS

Recombinant Mouse Anti-TIMP2 Recombinant Antibody (3A4) (CBMAB-XB1143-YC)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Zebrafish
Clone: 3A4
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-Timp2 Recombinant Antibody (F27P3A4) (CBMAB-T2496-YJ)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Mouse, Human
Clone: F27P3A4
Application*: IC, IF, IH, P, WB
Datasheet SDS

Rabbit Anti-TIMP2 Recombinant Antibody (CBYJT-3217) (CBMAB-T2495-YJ)

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Target: TIMP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: CBYJT-3217
Application*: WB
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (CBYJT-3216) (CBMAB-T2494-YJ)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Dog
Clone: CBYJT-3216
Application*: WB, F, IH, P
Datasheet SDS

Rabbit Anti-TIMP2 Recombinant Antibody (CBYJT-3214) (CBMAB-T2491-YJ)

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Target: TIMP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse
Clone: CBYJT-3214
Application*: WB
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (T2-101) (CBMAB-T2490-YJ)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: T2-101
Application*: IP, WB
Datasheet SDS

Goat Anti-TIMP2 Recombinant Antibody (CBYJT-3212) (CBMAB-T2488-YJ)

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Target: TIMP2
Host: Goat
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3212
Application*: WB, IH
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (CBYJT-3211) (CBMAB-T2487-YJ)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3211
Application*: E, WB, IH, IF
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (CBYJT-3210) (CBMAB-T2486-YJ)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3210
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (1554CT494.262.47) (CBMAB-T2485-YJ)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1554CT494.262.47
Application*: E, WB, P, IF, IC, F
Datasheet SDS

Mouse Anti-TIMP2 Recombinant Antibody (CBYJT-3209) (CBMAB-T2484-YJ)

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Target: TIMP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3209
Application*: EC
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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