Mouse Anti-TIMP2 Recombinant Antibody (CBYJT-3211) (CBMAB-T2487-YJ)

Name: Mouse Anti-TIMP2 Recombinant Antibody (CBYJT-3211)
SKU: CBMAB-T2487-YJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3211

Application

ELISA, WB, IHC, IF

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TIMP2 Gene(Protein Coding) TIMP Metallopeptidase Inhibitor 2

Introduction

TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, TIMP2 may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Entrez Gene ID

7077

UniProt ID

P16035

Alternative Names

TIMP Metallopeptidase Inhibitor 2; Tissue Inhibitor Of Metalloproteinases 2; CSC-21K; Tissue Inhibitor Of Metalloproteinase 2; Testicular Secretory Protein Li 57; Metalloproteinase Inhibitor 2; TIMP-2; DDC8

Function

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Biological Process

Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:GO_Central1 Publication
Biological Process negative regulation of metallopeptidase activitySource:UniProtKB1 Publication
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to organic substanceSource:GO_Central1 Publication

Cellular Location

Secreted

PTM

The activity of TIMP2 is dependent on the presence of disulfide bonds.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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