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Mouse Anti-TLE6 Recombinant Antibody (2E4) (CBMAB-A9132-LY)

The product is antibody recognizes TLE6. The antibody 2E4 immunoassay techniques such as: WB, ELISA.
See all TLE6 antibodies
Published Data
Fig. 1 FFPE sections from normal brain (n=13) or GBM (n=15) tissues were subjected to immunohistochemistry with anti-GRG6 antibody, followed by counterstaining with hematoxylin.
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Fig. 2 Western blot analysis of endogenous GRG6 expression in normal brain and GBM specimens, as indicated. β-ACTIN is shown as loading control.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E4
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
TLE6 (AAH20206, 1 a.a. ~ 449 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
Entrez Gene ID
79816
UniProt ID
Q9H808
Alternative Names
FLJ14009; GRG6; MGC14966
Function
Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (By similarity).
Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (By similarity).
Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (By similarity).
Isoform 1
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:26537248).
Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).
Biological Process
Biological Process actin filament organizationSource:UniProtKB
Biological Process embryonic process involved in female pregnancySource:UniProtKB1 Publication
Biological Process endoplasmic reticulum localizationSource:UniProtKB
Biological Process establishment of spindle localizationSource:UniProtKB
Biological Process mitochondrion localizationSource:UniProtKB
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:UniProtKB
Biological Process positive regulation of embryonic developmentSource:UniProtKB
Biological Process regulation of cell divisionSource:UniProtKB
Cellular Location
Nucleus
Isoform 1
Cytoplasm
Isoform 2
Cytoplasm
Involvement in disease
Preimplantation embryonic lethality 1 (PREMBL1):
A rare cause of female primary infertility. In affected women, ovulation proceeds normally and the retrieved oocytes appear normal, but zygote formation and division are severely impaired. Inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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