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Mouse Anti-Tle6 Recombinant Antibody (CBYJT-3302) (CBMAB-T2590-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Tle6 (Transducin-Like Enhancer Of Split 6). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all Tle6 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBYJT-3302
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Specific for an epitope mapping between amino acids 58-77 near the N-terminus of TLE6 of mouse origin
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 58-77

Target

Full Name
transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
Introduction
Tle6 has a positive regulation of neuron differentiation.
Entrez Gene ID
Human79816
Mouse114606
Rat299637
UniProt ID
HumanQ9H808
MouseQ9WVB3
RatF1LXS4
Alternative Names
Grg6; 1810057E06Rik
Function
Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (By similarity).
Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (By similarity).
Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (By similarity).
Isoform 1
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:26537248).
Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).
Biological Process
Biological Process actin filament organizationSource:UniProtKB
Biological Process embryonic process involved in female pregnancySource:UniProtKB1 Publication
Biological Process endoplasmic reticulum localizationSource:UniProtKB
Biological Process establishment of spindle localizationSource:UniProtKB
Biological Process mitochondrion localizationSource:UniProtKB
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:UniProtKB
Biological Process positive regulation of embryonic developmentSource:UniProtKB
Biological Process regulation of cell divisionSource:UniProtKB
Cellular Location
Nucleus
Isoform 1
Cytoplasm
Isoform 2
Cytoplasm
Involvement in disease
Preimplantation embryonic lethality 1 (PREMBL1):
A rare cause of female primary infertility. In affected women, ovulation proceeds normally and the retrieved oocytes appear normal, but zygote formation and division are severely impaired. Inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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