Mouse Anti-Tle6 Recombinant Antibody (CBYJT-3302) (CBMAB-T2590-YJ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (By similarity).
Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (By similarity).
Isoform 1
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:26537248).
Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).
Biological Process embryonic process involved in female pregnancySource:UniProtKB1 Publication
Biological Process endoplasmic reticulum localizationSource:UniProtKB
Biological Process establishment of spindle localizationSource:UniProtKB
Biological Process mitochondrion localizationSource:UniProtKB
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:UniProtKB
Biological Process positive regulation of embryonic developmentSource:UniProtKB
Biological Process regulation of cell divisionSource:UniProtKB
Isoform 1
Cytoplasm
Isoform 2
Cytoplasm
A rare cause of female primary infertility. In affected women, ovulation proceeds normally and the retrieved oocytes appear normal, but zygote formation and division are severely impaired. Inheritance is autosomal recessive.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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