TLE6

Tle6 has a positive regulation of neuron differentiation.

Full Name

transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)

Function

Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (By similarity).
Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (By similarity).
Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (By similarity).
Isoform 1
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:26537248).
Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).

Biological Process

Biological Process actin filament organizationSource:UniProtKB
Biological Process embryonic process involved in female pregnancySource:UniProtKB1 Publication
Biological Process endoplasmic reticulum localizationSource:UniProtKB
Biological Process establishment of spindle localizationSource:UniProtKB
Biological Process mitochondrion localizationSource:UniProtKB
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:UniProtKB
Biological Process positive regulation of embryonic developmentSource:UniProtKB
Biological Process regulation of cell divisionSource:UniProtKB

Cellular Location

Nucleus
Isoform 1
Cytoplasm
Isoform 2
Cytoplasm

Involvement in disease

Preimplantation embryonic lethality 1 (PREMBL1):
A rare cause of female primary infertility. In affected women, ovulation proceeds normally and the retrieved oocytes appear normal, but zygote formation and division are severely impaired. Inheritance is autosomal recessive.