Mouse Anti-TLR1 Recombinant Antibody (CBYJT-3336) (CBMAB-T2628-YJ)

Name: Mouse Anti-TLR1 Recombinant Antibody (CBYJT-3336)
SKU: CBMAB-T2628-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3336

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, 0.1% BSA

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TLR1 Gene(Protein Coding) Toll Like Receptor 1

Introduction

TLR1 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR1 is ubiquitously expressed, and at higher levels than other TLR genes.

Entrez Gene ID

7096

UniProt ID

Q15399

Alternative Names

Toll Like Receptor 1; Toll/Interleukin-1 Receptor-Like Protein; Toll-Like Receptor 1; TIL; CD281 Antigen; TIL. LPRS5; KIAA0012; Rsc786; CD281

Function

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852).
Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).
Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Biological Process

Biological Process cell activationSource:AgBase1 Publication
Biological Process cellular response to bacterial lipopeptideSource:GO_Central1 Publication
Biological Process cellular response to triacyl bacterial lipopeptideSource:UniProtKB1 Publication
Biological Process detection of triacyl bacterial lipopeptideSource:MGI1 Publication
Biological Process immune responseSource:ProtInc1 Publication
Biological Process inflammatory responseSource:GO_Central1 Publication
Biological Process innate immune responseSource:ComplexPortal2 Publications
Biological Process macrophage activationSource:UniProtKB1 Publication
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process positive regulation of interleukin-6 productionSource:UniProtKBBy Similarity
Biological Process positive regulation of interleukin-8 productionSource:ARUK-UCL1 Publication
Biological Process positive regulation of toll-like receptor 2 signaling pathwaySource:ARUK-UCL1 Publication
Biological Process positive regulation of tumor necrosis factor productionSource:UniProtKBBy Similarity
Biological Process signal transductionSource:ProtInc2 Publications
Biological Process toll-like receptor 1 signaling pathwaySource:InterPro
Biological Process toll-like receptor signaling pathwaySource:ComplexPortal1 Publication

Cellular Location

Cell membrane
Cytoplasmic vesicle, phagosome membrane
Membrane raft
Golgi apparatus
Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.

Topology

Extracellular: 25-580
Helical: 581-601
Cytoplasmic: 602-786

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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