TLR1

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]
Full Name
TLR1 Gene(Protein Coding) Toll Like Receptor 1
Function
Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852).
Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).
Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Biological Process
Biological Process cell activationSource:AgBase1 Publication
Biological Process cellular response to bacterial lipopeptideSource:GO_Central1 Publication
Biological Process cellular response to triacyl bacterial lipopeptideSource:UniProtKB1 Publication
Biological Process detection of triacyl bacterial lipopeptideSource:MGI1 Publication
Biological Process immune responseSource:ProtInc1 Publication
Biological Process inflammatory responseSource:GO_Central1 Publication
Biological Process innate immune responseSource:ComplexPortal2 Publications
Biological Process macrophage activationSource:UniProtKB1 Publication
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process positive regulation of interleukin-6 productionSource:UniProtKBBy Similarity
Biological Process positive regulation of interleukin-8 productionSource:ARUK-UCL1 Publication
Biological Process positive regulation of toll-like receptor 2 signaling pathwaySource:ARUK-UCL1 Publication
Biological Process positive regulation of tumor necrosis factor productionSource:UniProtKBBy Similarity
Biological Process signal transductionSource:ProtInc2 Publications
Biological Process toll-like receptor 1 signaling pathwaySource:InterPro
Biological Process toll-like receptor signaling pathwaySource:ComplexPortal1 Publication
Cellular Location
Cell membrane
Cytoplasmic vesicle, phagosome membrane
Membrane raft
Golgi apparatus
Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.
Topology
Extracellular: 25-580
Helical: 581-601
Cytoplasmic: 602-786
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Anti-TLR1 antibodies

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Mouse Anti-TLR1 Recombinant Antibody (CBYJT-3338) (CBMAB-T2630-YJ)

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Target: TLR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3338
Application*: F
Datasheet SDS

Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638)

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Target: TLR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3111
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-TLR1 Recombinant Antibody (CBT3593) (V2LY-0625-LY1637)

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Target: TLR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3593
Application*: IH, IC, F
Datasheet SDS

Recombinant Mouse Anti-TLR1 Antibody (CBHb172) (CBMAB-Hb1030-LY)

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Target: TLR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb172
Application*: FC, IHC-F, FuncS, Immuno assays, IF, IHC-P
Datasheet SDS

Rat Anti-TLR1 Recombinant Antibody (CBWJC-2432) (CBMAB-C3462WJ)

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Target: TLR1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBWJC-2432
Application*: F, IP
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Rat Anti-Tlr1 Recombinant Antibody (CBYJT-3344) (CBMAB-T2637-YJ)

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Target: Tlr1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3344
Application*: F
Datasheet SDS

Rat Anti-Tlr1 Recombinant Antibody (CBYJT-3342) (CBMAB-T2635-YJ)

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Target: Tlr1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3342
Application*: WB
Datasheet SDS

Mouse Anti-TLR1 Recombinant Antibody (CBYJT-3341) (CBMAB-T2634-YJ)

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Target: TLR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-3341
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-TLR1 Recombinant Antibody (CBYJT-3340) (CBMAB-T2633-YJ)

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Target: TLR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3340
Application*: F
Datasheet SDS

Mouse Anti-TLR1 Recombinant Antibody (GD2.F4) (CBMAB-T2632-YJ)

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Target: TLR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GD2.F4
Application*: F, FN, IF, C, P
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Mouse Anti-TLR1 Recombinant Antibody (CBYJT-3339) (CBMAB-T2631-YJ)

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Target: TLR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3339
Application*: F
Datasheet SDS

Mouse Anti-TLR1 Recombinant Antibody (CBYJT-3337) (CBMAB-T2629-YJ)

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Target: TLR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3337
Application*: F
Datasheet SDS

Mouse Anti-TLR1 Recombinant Antibody (CBYJT-3336) (CBMAB-T2628-YJ)

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Target: TLR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3336
Application*: F
Datasheet SDS

Mouse Anti-TLR1 Recombinant Antibody (CBYJT-3335) (CBMAB-T2627-YJ)

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Target: TLR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3335
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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