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Mouse Anti-TLR1 Recombinant Antibody (GD2.F4) (CBMAB-T2632-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TLR1 (Toll Like Receptor 1). The antibody can be used for immunoassay techniques, such as FC, FuncS, IF, IHC-Fr, IHC-P.
See all TLR1 antibodies
Published Data
Fig.1 Primary epidermal LCs, CD1c- MoLCs, and CD1c, MoDCs express TLR2.
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Fig.2 MoLCs at Day 6 were lysed, and for immunoblot analysis, the membranes were incubated with anti-TLR1, anti-TLR2, or anti-TLR6 antibody.
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Fig.3 CD4+ T cells were stimulated by anti-CD3/anti-CD28 beads without MoLCs. FACS plots show CFSE intensity of CD4+ cells after 5 days.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
GD2.F4
Antibody Isotype
IgG1
Application
FC, FuncS, IF, IHC-Fr, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.1% BSA
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TLR1 Gene(Protein Coding) Toll Like Receptor 1
Introduction
TLR1 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR1 is ubiquitously expressed, and at higher levels than other TLR genes.
Entrez Gene ID
7096
UniProt ID
Q15399
Alternative Names
Toll Like Receptor 1; Toll/Interleukin-1 Receptor-Like Protein; Toll-Like Receptor 1; TIL; CD281 Antigen; TIL. LPRS5; KIAA0012; Rsc786; CD281
Function
Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852).
Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).
Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Biological Process
Biological Process cell activationSource:AgBase1 Publication
Biological Process cellular response to bacterial lipopeptideSource:GO_Central1 Publication
Biological Process cellular response to triacyl bacterial lipopeptideSource:UniProtKB1 Publication
Biological Process detection of triacyl bacterial lipopeptideSource:MGI1 Publication
Biological Process immune responseSource:ProtInc1 Publication
Biological Process inflammatory responseSource:GO_Central1 Publication
Biological Process innate immune responseSource:ComplexPortal2 Publications
Biological Process macrophage activationSource:UniProtKB1 Publication
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process positive regulation of interleukin-6 productionSource:UniProtKBBy Similarity
Biological Process positive regulation of interleukin-8 productionSource:ARUK-UCL1 Publication
Biological Process positive regulation of toll-like receptor 2 signaling pathwaySource:ARUK-UCL1 Publication
Biological Process positive regulation of tumor necrosis factor productionSource:UniProtKBBy Similarity
Biological Process signal transductionSource:ProtInc2 Publications
Biological Process toll-like receptor 1 signaling pathwaySource:InterPro
Biological Process toll-like receptor signaling pathwaySource:ComplexPortal1 Publication
Cellular Location
Cell membrane
Cytoplasmic vesicle, phagosome membrane
Membrane raft
Golgi apparatus
Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.
Topology
Extracellular: 25-580
Helical: 581-601
Cytoplasmic: 602-786
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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