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Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638)


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Tested Data
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in ELISA
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in ELISA
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in WB
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in WB
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in WB
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in WB
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in IF
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in IF
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in FC
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in FC
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in IHC
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in IHC
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in IHC
Mouse Anti-TLR1 Recombinant Antibody (CBT3111) (V2LY-0625-LY1638) in IHC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3111
Antibody Isotype
IgG1
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human CD281 (AA: extra 172-425) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:100-1:500
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TLR1 Gene(Protein Coding) Toll Like Receptor 1
Entrez Gene ID
7096
Function
Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852).
Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).
Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Biological Process
Biological Process cell activationSource:AgBase1 Publication
Biological Process cellular response to bacterial lipopeptideSource:GO_Central1 Publication
Biological Process cellular response to triacyl bacterial lipopeptideSource:UniProtKB1 Publication
Biological Process detection of triacyl bacterial lipopeptideSource:MGI1 Publication
Biological Process immune responseSource:ProtInc1 Publication
Biological Process inflammatory responseSource:GO_Central1 Publication
Biological Process innate immune responseSource:ComplexPortal2 Publications
Biological Process macrophage activationSource:UniProtKB1 Publication
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process positive regulation of interleukin-6 productionSource:UniProtKBBy Similarity
Biological Process positive regulation of interleukin-8 productionSource:ARUK-UCL1 Publication
Biological Process positive regulation of toll-like receptor 2 signaling pathwaySource:ARUK-UCL1 Publication
Biological Process positive regulation of tumor necrosis factor productionSource:UniProtKBBy Similarity
Biological Process signal transductionSource:ProtInc2 Publications
Biological Process toll-like receptor 1 signaling pathwaySource:InterPro
Biological Process toll-like receptor signaling pathwaySource:ComplexPortal1 Publication
Cellular Location
Cell membrane
Cytoplasmic vesicle, phagosome membrane
Membrane raft
Golgi apparatus
Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.
Topology
Extracellular: 25-580
Helical: 581-601
Cytoplasmic: 602-786
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For research use only. Not intended for any clinical use.

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