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Mouse Anti-TMED1 Recombinant Antibody (CBYJT-3459) (CBMAB-T2783-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TMED1 (Transmembrane P24 Trafficking Protein 1). The antibody can be used for immunoassay techniques, such as WB, ICC, IF.
See all TMED1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3459
Antibody Isotype
IgG1
Application
WB, ICC, IF

Basic Information

Immunogen
Full length human recombinant protein of human TMED1(NP_006849) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transmembrane P24 Trafficking Protein 1
Introduction
TMED1 belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. TMED1 was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may function in innate immunity. TMED1 lacks any similarity to other interleukin 1 ligands.
Entrez Gene ID
11018
UniProt ID
Q13445
Alternative Names
Transmembrane P24 Trafficking Protein 1; Transmembrane Emp24 Protein Transport Domain Containing 1; Putative T1/ST2 Receptor-Binding Protein; P24 Family Protein Gamma-1; IL1RL1LG; Il1rl1l; Tp24; Transmembrane Emp24 Domain-Containing Protein 1
Function
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1 (PubMed:23319592).
Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325).
Biological Process
Biological Process cell-cell signalingSource:ProtInc1 Publication
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportSource:GO_Central1 Publication
Biological Process Golgi organizationSource:GO_Central1 Publication
Biological Process innate immune responseSource:UniProtKB-KW
Biological Process intracellular protein transportSource:GO_Central1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Cellular Location
Cell membrane
Endoplasmic reticulum membrane
Golgi apparatus, cis-Golgi network membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Topology
Extracellular: 24-194
Helical: 195-215
Cytoplasmic: 216-227
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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