Mouse Anti-TMED1 Recombinant Antibody (CBYJT-3459) (CBMAB-T2783-YJ)

Name: Mouse Anti-TMED1 Recombinant Antibody (CBYJT-3459)
SKU: CBMAB-T2783-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3459

Application

WB, ICC, IF

Immunogen

Full length human recombinant protein of human TMED1(NP_006849) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Transmembrane P24 Trafficking Protein 1

Introduction

TMED1 belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. TMED1 was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may function in innate immunity. TMED1 lacks any similarity to other interleukin 1 ligands.

Entrez Gene ID

11018

UniProt ID

Q13445

Alternative Names

Transmembrane P24 Trafficking Protein 1; Transmembrane Emp24 Protein Transport Domain Containing 1; Putative T1/ST2 Receptor-Binding Protein; P24 Family Protein Gamma-1; IL1RL1LG; Il1rl1l; Tp24; Transmembrane Emp24 Domain-Containing Protein 1

Function

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1 (PubMed:23319592).
Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325).

Biological Process

Biological Process cell-cell signalingSource:ProtInc1 Publication
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportSource:GO_Central1 Publication
Biological Process Golgi organizationSource:GO_Central1 Publication
Biological Process innate immune responseSource:UniProtKB-KW
Biological Process intracellular protein transportSource:GO_Central1 Publication
Biological Process signal transductionSource:ProtInc1 Publication

Cellular Location

Cell membrane
Endoplasmic reticulum membrane
Golgi apparatus, cis-Golgi network membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane

Topology

Extracellular: 24-194
Helical: 195-215
Cytoplasmic: 216-227

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-TMED1 Recombinant Antibody (CBYJT-3460) (CAT#: CBMAB-T2784-YJ)

Isotype control

For research use only. Not intended for any clinical use.

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