TMED1

TMED1 belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. TMED1 was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may function in innate immunity. TMED1 lacks any similarity to other interleukin 1 ligands.

Full Name

Transmembrane P24 Trafficking Protein 1

Function

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1 (PubMed:23319592).
Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325).

Biological Process

Biological Process cell-cell signalingSource:ProtInc1 Publication
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportSource:GO_Central1 Publication
Biological Process Golgi organizationSource:GO_Central1 Publication
Biological Process innate immune responseSource:UniProtKB-KW
Biological Process intracellular protein transportSource:GO_Central1 Publication
Biological Process signal transductionSource:ProtInc1 Publication

Cellular Location

Cell membrane
Endoplasmic reticulum membrane
Golgi apparatus, cis-Golgi network membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane

Topology

Extracellular: 24-194
Helical: 195-215
Cytoplasmic: 216-227