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Mouse Anti-TMPRSS11D Recombinant Antibody (CBYJT-3555) (CBMAB-T2882-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TMPRSS11D (Transmembrane Protease, Serine 11D). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TMPRSS11D antibodies
Published Data
Fig.1 There is strongly positive anti-HAT immunostaining of the basal part of the ileal epithelial cells (Ep), but only weak positive immunostaining of occasional lymphocytes (Ly) within the villus core.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3555
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transmembrane Protease, Serine 11D
Introduction
TMPRSS11D is a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. TMPRSS11D may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
Entrez Gene ID
9407
UniProt ID
O60235
Alternative Names
Transmembrane Protease, Serine 11D; Airway Trypsin-Like Protease; HAT; Transmembrane Protease Serine 11D; Airway Trypsin Like Protease; EC 3.4.21
Function
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.
Biological Process
Biological Process proteolysisSource:UniProtKB1 Publication
Biological Process respiratory gaseous exchange by respiratory systemSource:ProtInc1 Publication
Cellular Location
Cell membrane
Activated by cleavage and secreted.
Transmembrane protease serine 11D catalytic chain
Secreted
Activated by cleavage and secreted.
Topology
Cytoplasmic: 1-20
Helical: 21-41
Extracellular: 42-418
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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