Mouse Anti-TMPRSS11D Recombinant Antibody (CBYJT-3555) (CBMAB-T2882-YJ)

Name: Mouse Anti-TMPRSS11D Recombinant Antibody (CBYJT-3555)
SKU: CBMAB-T2882-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3555

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Transmembrane Protease, Serine 11D

Introduction

TMPRSS11D is a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. TMPRSS11D may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.

Entrez Gene ID

9407

UniProt ID

O60235

Alternative Names

Transmembrane Protease, Serine 11D; Airway Trypsin-Like Protease; HAT; Transmembrane Protease Serine 11D; Airway Trypsin Like Protease; EC 3.4.21

Function

May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.

Biological Process

Biological Process proteolysisSource:UniProtKB1 Publication
Biological Process respiratory gaseous exchange by respiratory systemSource:ProtInc1 Publication

Cellular Location

Cell membrane
Activated by cleavage and secreted.
Transmembrane protease serine 11D catalytic chain
Secreted
Activated by cleavage and secreted.

Topology

Cytoplasmic: 1-20
Helical: 21-41
Extracellular: 42-418

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-TMPRSS11D Recombinant Antibody (CBFYH-2795) (CAT#: CBMAB-H3863-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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