TMPRSS11D

TMPRSS11D is a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. TMPRSS11D may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.

Full Name

Transmembrane Protease, Serine 11D

Function

May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.

Biological Process

Biological Process proteolysisSource:UniProtKB1 Publication
Biological Process respiratory gaseous exchange by respiratory systemSource:ProtInc1 Publication

Cellular Location

Cell membrane
Activated by cleavage and secreted.
Transmembrane protease serine 11D catalytic chain
Secreted
Activated by cleavage and secreted.

Topology

Cytoplasmic: 1-20
Helical: 21-41
Extracellular: 42-418