Human Recombinant TMPRSS11D protein, His Tag (V2LY-0526-LY7292)

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Datasheet
SDS
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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Human
Tag
His Tag
Protein Construction
This product is Human Recombinant TMPRSS11D protein, His Tag consist of Amino Acid: 187-417 and predicts a molecular mass of 27.6 kDa.
Molecule Mass
27.6 kDa
Verified
HPLC
Sequence
Amino Acid: 187-417
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile MES, NaCl, Trehalose, Arginine, CaCl2, MgCl2, ZnCl2
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
Transmembrane Protease, Serine 11D
Function
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.
Biological Process
Biological Process proteolysisSource:UniProtKB1 Publication
Biological Process respiratory gaseous exchange by respiratory systemSource:ProtInc1 Publication
Cellular Location
Cell membrane
Activated by cleavage and secreted.
Transmembrane protease serine 11D catalytic chain
Secreted
Activated by cleavage and secreted.
Topology
Cytoplasmic: 1-20
Helical: 21-41
Extracellular: 42-418
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TMPRSS11D Recombinant Antibody (CBYJT-3555) (CAT#: CBMAB-T2882-YJ)

Mouse Anti-TMPRSS11D Recombinant Antibody (CBFYH-2795) (CAT#: CBMAB-H3863-FY)

Isotype control

For research use only. Not intended for any clinical use.

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