Mouse Anti-TNFRSF10D Recombinant Antibody (CBWJC-4519) (CBMAB-C5912WJ)

Name: Mouse Anti-TNFRSF10D Recombinant Antibody (CBWJC-4519)
SKU: CBMAB-C5912WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBWJC-4519

Application

IP, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TNFRSF10D Gene(Protein Coding)

TNF Receptor Superfamily Member 10d

Introduction

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]

Entrez Gene ID

8793

UniProt ID

Q9UBN6

Alternative Names

TNF Receptor Superfamily Member 10d; Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated Death Domain; TNF-Related Apoptosis-Inducing Ligand Receptor 4; TRAIL Receptor With A Truncated Death Domain; Decoy Receptor 2; TRAIL Receptor 4; TRAIL-R4; TRAILR4;

Function

Receptor for the cytotoxic ligand TRAIL (PubMed:9430226).
Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis (PubMed:9537512).
Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway (PubMed:9382840, PubMed:9430226).

Biological Process

Biological Process apoptotic process Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process signal transduction Source:ProtInc1 Publication

Cellular Location

Membrane

Topology

Extracellular: 56-211
Helical: 212-232
Cytoplasmic: 233-386

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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