TNFRSF10D
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]
Full Name
TNFRSF10D Gene(Protein Coding)
TNF Receptor Superfamily Member 10d
TNF Receptor Superfamily Member 10d
Function
Receptor for the cytotoxic ligand TRAIL (PubMed:9430226).
Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis (PubMed:9537512).
Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway (PubMed:9382840, PubMed:9430226).
Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis (PubMed:9537512).
Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway (PubMed:9382840, PubMed:9430226).
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Membrane
Topology
Extracellular: 56-211
Helical: 212-232
Cytoplasmic: 233-386
Helical: 212-232
Cytoplasmic: 233-386
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Anti-TNFRSF10D antibodies
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CompareTarget: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4520
Application*: E
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4519
Application*: IP, WB
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4518
Application*: E
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2434
Application*: F
Target: TNFRSF10D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBYJT-3679
Application*: WB, IP
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3678
Application*: F, MC
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3677
Application*: WB, B, N
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HS402
Application*: F, IC, IH, IP
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3676
Application*: E
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-R27
Application*: F
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3675
Application*: F, IP, WB
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3674
Application*: WB, F, N
Target: TNFRSF10D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3673
Application*: E
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3672
Application*: WB, F, N, MC, EC
Target: TNFRSF10D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3671
Application*: P
Target: TNFRSF10D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCD-519
Application*: WB, P, IC
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TRAIL-R4-01
Application*: F
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-P30
Application*: WB, IP
Target: TNFRSF10D
Sensitivity: 0.058 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates, Ascites, tissue homogenates or other biological fluids
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: TNFRSF10D
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-206
Tag: His Tag
Target: TNFRSF10D
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-206
Tag: hFc Tag
Target: TNFRSF10D
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-211
Tag: His Tag
Target: TNFRSF10D
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-211
Tag: hFc Tag
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBT4040
Application*: WB
Target: TNFRSF10D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT3197
Application*: WB
Target: TNFRSF10D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D13H4
Application*: WB, IP
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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