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Rabbit Anti-TNFRSF10D Recombinant Antibody (CBYCD-519) (CBMAB-D2315-YC)

Provided herein is a Rabbit monoclonal antibody, which binds to TNF Receptor Superfamily Member 10d (TNFRSF10D). The antibody can be used for immunoassay techniques, such as WB, IHC-P, ICC.
See all TNFRSF10D antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYCD-519
Antibody Isotype
IgG
Application
WB, IHC-P, ICC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFRSF10D Gene(Protein Coding)


TNF Receptor Superfamily Member 10d
Introduction
TNFRSF10D is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.
Entrez Gene ID
8793
UniProt ID
Q9UBN6
Alternative Names
TNF Receptor Superfamily Member 10d; Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated Death Domain; TNF-Related Apoptosis-Inducing Ligand Receptor 4; TRAIL Receptor With A Truncated Death Domain; Decoy Receptor 2; TRAIL Receptor 4; TRAIL-R4; TRAILR4;
Function
Receptor for the cytotoxic ligand TRAIL (PubMed:9430226).
Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis (PubMed:9537512).
Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway (PubMed:9382840, PubMed:9430226).
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Membrane
Topology
Extracellular: 56-211
Helical: 212-232
Cytoplasmic: 233-386
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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