Mouse Anti-TNFSF10 Recombinant Antibody (CBYJT-3903) (CBMAB-T3304-YJ)

Name: Mouse Anti-TNFSF10 Recombinant Antibody (CBYJT-3903)
SKU: CBMAB-T3304-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3903

Application

WB, ELISA, Neut, Inhib

Immunogen

Recombinant full length protein (Human).

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TNFSF10

Introduction

TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TNFSF10 binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF10 may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of TNFSF10 to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.

Entrez Gene ID

Human	8743
Mouse	22035

UniProt ID

Human	P50591
Mouse	P50592

Alternative Names

TNF Superfamily Member 10; Tumor Necrosis Factor (Ligand) Superfamily, Member 10; Apo-2 Ligand; Apo-2L; APO2L; TRAIL; Tumor Necrosis Factor Apoptosis-Inducing Ligand Splice Variant Delta; Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10; Tumor Necrosis Factor Ligand Superfamily Member 10; Tumor Necrosis Factor (Ligand) Family, Member 10

Function

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).
Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Biological Process

Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process immune response Source:InterPro
Biological Process male gonad development Source:Ensembl
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:UniProtKB3 Publications
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB3 Publications
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of release of cytochrome c from mitochondria Source:UniProtKB1 Publication
Biological Process response to insulin Source:Ensembl
Biological Process signal transduction Source:ProtInc2 Publications

Cellular Location

Cell membrane
Secreted
Exists both as membrane-bound and soluble form.

Topology

Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-281

PTM

Tyrosine phosphorylated by PKDCC/VLK.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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