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TNFSF10

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Full Name

TNFSF10

Function

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).
Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Biological Process

Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process immune response Source:InterPro
Biological Process male gonad development Source:Ensembl
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:UniProtKB3 Publications
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB3 Publications
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of release of cytochrome c from mitochondria Source:UniProtKB1 Publication
Biological Process response to insulin Source:Ensembl
Biological Process signal transduction Source:ProtInc2 Publications

Cellular Location

Cell membrane
Secreted
Exists both as membrane-bound and soluble form.

Topology

Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-281

PTM

Tyrosine phosphorylated by PKDCC/VLK.

Anti-TNFSF10 antibodies

Mouse Anti-TNFSF10 Recombinant Antibody (CBWJC-4547) (CBMAB-C5943WJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBWJC-4547

Application*: WB

Mouse Anti-TNFSF10 Recombinant Antibody (CBWJC-2451) (CBMAB-C3514WJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-2451

Application*: FN

Mouse Anti-TNFSF10 Recombinant Antibody (CBXS-0933) (CBMAB-S3847-CQ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-0933

Application*: WB, P, SE

Rat Anti-Tnfsf10 Recombinant Antibody (N2B2) (CBMAB-T3309-YJ)

SDS

Target: Tnfsf10

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: N2B2

Application*: F

Mouse Anti-TNFSF10 Antibody (11F2) (CBMAB-1650CQ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 11F2

Application*: E, M

Mouse Anti-TNFSF10 Antibody (12C8) (CBMAB-1651CQ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 12C8

Application*: E, M

Mouse Anti-TNFSF10 Antibody (13B4) (CBMAB-1652CQ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 13B4

Application*: E, M

Mouse Anti-TNFSF10 (AA 95-281) Recombinant Antibody (CBFYC-3186) (CBMAB-C3263-FY)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-3186

Application*: F, FN

Mouse Anti-TNFSF10 Recombinant Antibody (CBFYC-3187) (CBMAB-C3264-FY)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYC-3187

Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-TNFSF10 Recombinant Antibody (CBYJT-3897) (CBMAB-T3292-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3897

Application*: WB, F, FN

Mouse Anti-TNFSF10 Recombinant Antibody (55B709.3) (CBMAB-T3293-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 55B709.3

Application*: WB, P

Mouse Anti-TNFSF10 Recombinant Antibody (CBYJT-3898) (CBMAB-T3294-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3898

Application*: WB, P, F

Mouse Anti-TNFSF10 Recombinant Antibody (CBYJT-3899) (CBMAB-T3295-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3899

Application*: IH

Mouse Anti-TNFSF10 Recombinant Antibody (CBMAB-T3296-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Application*: F

Mouse Anti-TNFSF10 Recombinant Antibody (B-T24) (CBMAB-T3297-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: B-T24

Application*: E, F, FN

Rabbit Anti-TNFSF10 Recombinant Antibody (CBYJT-3900) (CBMAB-T3298-YJ)

SDS

Target: TNFSF10

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-3900

Application*: WB, IP, P, IF, F

Mouse Anti-TNFSF10 Recombinant Antibody (HS501) (CBMAB-T3299-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: HS501

Application*: WB

Mouse Anti-TNFSF10 Recombinant Antibody (CBYJT-3901) (CBMAB-T3300-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-3901

Application*: F

Mouse Anti-TNFSF10 Recombinant Antibody (SB91a) (CBMAB-T3301-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: SB91a

Application*: E

Mouse Anti-TNFSF10 Recombinant Antibody (SB91c) (CBMAB-T3302-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: SB91c

Application*: E

Mouse Anti-TNFSF10 Recombinant Antibody (CBYJT-3902) (CBMAB-T3303-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-3902

Application*: E, F, IP

Mouse Anti-TNFSF10 Recombinant Antibody (CBYJT-3903) (CBMAB-T3304-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBYJT-3903

Application*: WB, E, N, I

Mouse Anti-TNFSF10 Recombinant Antibody (CBYJT-3904) (CBMAB-T3305-YJ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3904

Application*: EC

Rat Anti-Tnfsf10 Recombinant Antibody (CBYJT-3906) (CBMAB-T3307-YJ)

SDS

Target: Tnfsf10

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYJT-3906

Application*: WB

Mouse Anti-TNFSF10 Recombinant Antibody (2E5) (CBMAB-C0879-LY)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2E5

Application*: F, FN

Mouse Anti-TNFSF10 Recombinant Antibody (18) (CBMAB-C3443-LY)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 18

Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-TNFSF10 Recombinant Antibody (CBCNC-713) (CBMAB-C4372-CN)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNC-713

Application*: P, E, FN, WB

Mouse Anti-TNFSF10 Recombinant Antibody (CBXC-2103) (CBMAB-C2104-CQ)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-2103

Application*: F, FN

Mouse Anti-TNFSF10 Recombinant Antibody (RIK-2) (CBMAB-C12589-LY)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: RIK-2

Application*: F

Rat Anti-Tnfsf10 Recombinant Antibody (CBYJT-3907) (CBMAB-T3308-YJ)

SDS

Target: Tnfsf10

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBYJT-3907

Application*: WB, EC

Mouse Anti-TNFSF10 Recombinant Antibody (RIK-1) (CBMAB-C12591-LY)

SDS

Target: TNFSF10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: RIK-1

Application*: F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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