TNFSF10
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Full Name
TNFSF10
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).
Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Biological Process
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process immune response Source:InterPro
Biological Process male gonad development Source:Ensembl
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:UniProtKB3 Publications
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB3 Publications
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of release of cytochrome c from mitochondria Source:UniProtKB1 Publication
Biological Process response to insulin Source:Ensembl
Biological Process signal transduction Source:ProtInc2 Publications
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process immune response Source:InterPro
Biological Process male gonad development Source:Ensembl
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:UniProtKB3 Publications
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB3 Publications
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of release of cytochrome c from mitochondria Source:UniProtKB1 Publication
Biological Process response to insulin Source:Ensembl
Biological Process signal transduction Source:ProtInc2 Publications
Cellular Location
Cell membrane
Secreted
Exists both as membrane-bound and soluble form.
Secreted
Exists both as membrane-bound and soluble form.
Topology
Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-281
Helical: 18-38
Extracellular: 39-281
PTM
Tyrosine phosphorylated by PKDCC/VLK.
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Anti-TNFSF10 antibodies
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CompareTarget: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: RIK-1
Application*: F
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: RIK-2
Application*: F
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-713
Application*: P, E, FN, WB
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBWJC-4547
Application*: WB
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2451
Application*: FN
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0933
Application*: WB, P, SE
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2103
Application*: F, FN
Target: Tnfsf10
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: N2B2
Application*: F
Target: Tnfsf10
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3907
Application*: WB, EC
Target: Tnfsf10
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3906
Application*: WB
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3904
Application*: EC
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJT-3903
Application*: WB, E, N, I
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3902
Application*: E, F, IP
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: SB91c
Application*: E
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: SB91a
Application*: E
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3901
Application*: F
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HS501
Application*: WB
Target: TNFSF10
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3900
Application*: WB, IP, P, IF, F
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-T24
Application*: E, F, FN
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Application*: F
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3899
Application*: IH
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3898
Application*: WB, P, F
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 55B709.3
Application*: WB, P
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3897
Application*: WB, F, FN
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-3187
Application*: WB, IC, P, C, E, IP, IF, F
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3186
Application*: F, FN
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 18
Application*: WB, IC, P, C, E, IP, IF, F
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E5
Application*: F, FN
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13B4
Application*: E, M
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 12C8
Application*: E, M
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 11F2
Application*: E, M
Target: TNFSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2476
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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