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Rat Anti-Tnfsf10 Recombinant Antibody (N2B2) (CBMAB-T3309-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Tnfsf10 (Tumor Necrosis Factor (Ligand) Superfamily, Member 10). The antibody can be used for immunoassay techniques, such as FC.
See all Tnfsf10 antibodies
Published Data
Fig.1 HEK293T cells were transiently transfected with plasmids coding for Flag-hIRE1, Flag-hRIPK1 and/or hTNFR1, and IRE1.
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Fig.2 Phenotype of liver natural killer cells under starvation.
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Fig.3 The effect of recombinant heat shock protein 70 on TRAIL expression.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
N2B2
Antibody Isotype
IgG2a, κ
Application
FC

Basic Information

Immunogen
TNFSF10 / TRAIL antibody was raised against mouse TNFSF10
Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFSF10
Introduction
Tnfsf10 is a cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. It induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Entrez Gene ID
22035
UniProt ID
P50592
Alternative Names
TL2; Ly81; Trail; APO-2L; Tnlg6a; AI448571; A330042I21Rik
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).
Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Biological Process
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process immune response Source:InterPro
Biological Process male gonad development Source:Ensembl
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:UniProtKB3 Publications
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB3 Publications
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of release of cytochrome c from mitochondria Source:UniProtKB1 Publication
Biological Process response to insulin Source:Ensembl
Biological Process signal transduction Source:ProtInc2 Publications
Cellular Location
Cell membrane
Secreted
Exists both as membrane-bound and soluble form.
Topology
Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-281
PTM
Tyrosine phosphorylated by PKDCC/VLK.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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