Mouse Anti-TNFSF8 Recombinant Antibody (4E3) (CBMAB-A9382-LY)

Name: Mouse Anti-TNFSF8 Recombinant Antibody (4E3)
SKU: CBMAB-A9382-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4E3

Application

WB, ELISA

Immunogen

TNFSF8 (AAH93630.1, 63 a.a. ~ 234 a.a) partial recombinant protein.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TNFSF8 Gene(Protein Coding) TNF Superfamily Member 8

Introduction

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. [provided by RefSeq]

Entrez Gene ID

944

UniProt ID

P32971

Alternative Names

CD153; CD30L; CD30LG; MGC138144

Function

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

Biological Process

Biological Process CD8-positive, alpha-beta T cell differentiation Source:GO_Central1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process defense response to Gram-positive bacterium Source:Ensembl
Biological Process immune response Source:InterPro
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process regulation of T cell proliferation Source:GO_Central1 Publication

Cellular Location

Membrane

Topology

Cytoplasmic: 1-37
Helical: 38-62
Extracellular: 63-234

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TNFSF8 Matched Antibody Pair (1247) (CAT#: APMAB-1247LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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