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TNFSF8 Matched Antibody Pair (1247) (APMAB-1247LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-TNFSF8 monoclonal, IgG1 antibody, 100 ug
Detection Antibody
Anti-TNFSF8 Biotinylated mouse monoclonal, IgG1 antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Alternative Names
TNF Superfamily Member 8; Tumor Necrosis Factor (Ligand) Superfamily, Member 8; CD153 Antigen; CD30 Ligand; CD30LG; CD30-L; CD30L;
Entrez Gene ID
944
UniProt ID
P32971
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For research use only. Not intended for any clinical use.

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