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TNFSF8

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Full Name

TNFSF8 Gene(Protein Coding) TNF Superfamily Member 8

Function

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

Biological Process

Biological Process CD8-positive, alpha-beta T cell differentiation Source:GO_Central1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process defense response to Gram-positive bacterium Source:Ensembl
Biological Process immune response Source:InterPro
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process regulation of T cell proliferation Source:GO_Central1 Publication

Cellular Location

Membrane

Topology

Cytoplasmic: 1-37
Helical: 38-62
Extracellular: 63-234

Anti-TNFSF8 antibodies

Mouse Anti-TNFSF8 Recombinant Antibody (CBYJT-4001) (CBMAB-T3414-YJ)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYJT-4001

Application*: WB

Mouse Anti-TNFSF8 Recombinant Antibody (CBYJT-4002) (CBMAB-T3415-YJ)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-4002

Application*: E, WB

Mouse Anti-TNFSF8 Recombinant Antibody (CBYJT-4007) (CBMAB-T3420-YJ)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-4007

Application*: E

Mouse Anti-TNFSF8 Recombinant Antibody (CBYJT-4008) (CBMAB-T3421-YJ)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-4008

Application*: E, WB

Rat Anti-Tnfsf8 Recombinant Antibody (CBYJT-4012) (CBMAB-T3425-YJ)

SDS

Target: Tnfsf8

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYJT-4012

Application*: WB

Rat Anti-Tnfsf8 Recombinant Antibody (CBYJT-4014) (CBMAB-T3427-YJ)

SDS

Target: Tnfsf8

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYJT-4014

Application*: F, IH, FN, IP

Mouse Anti-TNFSF8 Recombinant Antibody (CBYY-C1190) (CBMAB-C2627-YY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYY-C1190

Application*: WB

Mouse Anti-TNFSF8 Recombinant Antibody (MM0168-3G56) (CBMAB-C12603-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: MM0168-3G56

Application*: WB

Rat Anti-TNFSF8 Recombinant Antibody (RM0353-9C33) (CBMAB-C12604-LY)

SDS

Target: TNFSF8

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: RM0353-9C33

Application*: WB

Mouse Anti-TNFSF8 Recombinant Antibody (4E3) (CBMAB-A9382-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4E3

Application*: WB, E

Mouse Anti-TNFSF8 Recombinant Antibody (4E4) (CBMAB-A9383-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4E4

Application*: WB, E

Mouse Anti-TNFSF8 Recombinant Antibody (4E6) (CBMAB-A9384-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4E6

Application*: WB, E

Mouse Anti-TNFSF8 Recombinant Antibody (3G9) (CBMAB-A9385-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3G9

Application*: WB, E

Mouse Anti-TNFSF8 Recombinant Antibody (4A10) (CBMAB-A9386-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4A10

Application*: WB, E

Mouse Anti-TNFSF8 Recombinant Antibody (4A6) (CBMAB-A9387-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4A6

Application*: E, E

Mouse Anti-TNFSF8 Recombinant Antibody (4A9) (CBMAB-A9388-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4A9

Application*: E, E

Mouse Anti-TNFSF8 Recombinant Antibody (4C6) (CBMAB-A9389-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4C6

Application*: E, E

Mouse Anti-TNFSF8 Recombinant Antibody (116614) (CBMAB-C0215-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 116614

Application*: F, N, MC

Mouse Anti-TNFSF8 Recombinant Antibody (116615) (CBMAB-C2466-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 116615

Application*: WB

Mouse Anti-TNFSF8 Recombinant Antibody (3G56) (CBMAB-C6161-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 3G56

Application*: WB

Rat Anti-TNFSF8 Recombinant Antibody (82414) (CBMAB-C8957-LY)

SDS

Target: TNFSF8

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 82414

Application*: WB, EC

Mouse Anti-TNFSF8 Recombinant Antibody (CBFYC-3193) (CBMAB-C3270-FY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-3193

Application*: F, N

Mouse Anti-TNFSF8 Recombinant Antibody (CBXC-0956) (CBMAB-C1218-CQ)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-0956

Application*: F

Rat Anti-TNFSF8 Recombinant Antibody (RM153) (CBMAB-C2063-CQ)

SDS

Target: TNFSF8

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: RM153

Application*: F

Mouse Anti-TNFSF8 Recombinant Antibody (2E11) (CBMAB-C13586-LY)

SDS

Target: TNFSF8

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human

Clone: 2E11

Application*: E, WB

TNFSF8 Matched Antibody Pair (1247) (APMAB-1247LY)

SDS

Target: TNFSF8

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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