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Mouse Anti-TNFSF8 Recombinant Antibody (CBYJT-4008) (CBMAB-T3421-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNFSF8 (TNF Superfamily Member 8). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TNFSF8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4008
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
TNFSF8 (AAH93630.1, aa63-234) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 63-234

Target

Full Name
TNFSF8 Gene(Protein Coding) TNF Superfamily Member 8
Introduction
TNFSF8 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. TNFSF8 was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas.
Entrez Gene ID
944
UniProt ID
P32971
Alternative Names
TNF Superfamily Member 8; Tumor Necrosis Factor (Ligand) Superfamily, Member 8; CD153 Antigen; CD30 Ligand; CD30LG; CD30-L; CD30L
Function
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
Biological Process
Biological Process CD8-positive, alpha-beta T cell differentiation Source:GO_Central1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process defense response to Gram-positive bacterium Source:Ensembl
Biological Process immune response Source:InterPro
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process regulation of T cell proliferation Source:GO_Central1 Publication
Cellular Location
Membrane
Topology
Cytoplasmic: 1-37
Helical: 38-62
Extracellular: 63-234
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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