Sign in or Register   Sign in or Register
  |  

Rat Anti-TNFSF8 Recombinant Antibody (RM153) (CBMAB-C2063-CQ)

This product is a rat antibody that recognizes TNFSF8. The antibody RM153 can be used for immunoassay techniques such as: FC.
See all TNFSF8 antibodies
Published Data
Fig.1 Zymosan induces IL-17 production in splenic LTi-like cells in vivo.
...View More
Fig.2 MSC treatment reduces lesion development.
...View More

Summary

Host Animal
Rat
Specificity
Mouse
Clone
RM153
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Mouse CD153/CHO cells
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFSF8 Gene(Protein Coding) TNF Superfamily Member 8
Introduction
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
21949
UniProt ID
P32972
Alternative Names
TNF Superfamily Member 8; Tumor Necrosis Factor (Ligand) Superfamily, Member 8; CD153 Antigen; CD30 Ligand; CD30LG; CD30-L; CD30L;
Function
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
Biological Process
Biological Process CD8-positive, alpha-beta T cell differentiation Source:GO_Central1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process defense response to Gram-positive bacterium Source:Ensembl
Biological Process immune response Source:InterPro
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process regulation of T cell proliferation Source:GO_Central1 Publication
Cellular Location
Membrane
Topology
Cytoplasmic: 1-37
Helical: 38-62
Extracellular: 63-234
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-TNFSF8 Recombinant Antibody (RM153)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare