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Rabbit Anti-TNFSF9 Recombinant Antibody (014) (CBMAB-C0047-LY)

This product is antibody recognizes TNFSF9. The antibody 014 immunoassay techniques such as: ELISA, FC, ICC/IF, IF.
See all TNFSF9 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
014
Antibody Isotype
IgG
Application
ELISA, FC, ICC/IF, IF

Basic Information

Immunogen
Recombinant Mouse 4-1BBL / CD137L / TNFSF9 protein
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TNFSF9 Gene(Protein Coding) TNF Superfamily Member 9
Introduction
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
Entrez Gene ID
21950
UniProt ID
P41274
Function
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Biological Process
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process immune response Source:InterPro
Biological Process positive regulation of activated T cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of cytotoxic T cell differentiation Source:GO_Central1 Publication
Biological Process regulation of apoptotic process Source:GO_Central1 Publication
Biological Process regulation of T cell proliferation Source:GO_Central1 Publication
Cellular Location
Membrane
Topology
Cytoplasmic: 1-28
Helical: 29-49
Extracellular: 50-254
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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